Fut2 fucosyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fut2provided by RGD
Official Full Name: fucosyltransferase 2provided by RGD
Primary source: RGD:2639
See related: EnsemblRapid:ENSRNOG00000021011 AllianceGenome:RGD:2639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ftc; Futb
Summary: Enables galactoside 2-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in vitamin B12 deficiency. Orthologous to human FUT2 (fucosyltransferase 2 (H blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 11.6), Thymus (RPKM 10.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105256013..105276828, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96119549..96139567, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101631633..101651668, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-(1,2)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1,2)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables galactoside 2-alpha-L-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside 2-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactoside 2-alpha-L-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables galactoside 2-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in fucosylation	IEA Inferred from Electronic Annotation more info
involved_in fucosylation	ISO Inferred from Sequence Orthology more info
involved_in glycolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactoside alpha-(1,2)-fucosyltransferase 2

Names: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; alpha 1,2-fucosyltransferase B; alpha 1-2 fucosyltransferase; alpha 12-fucosyltransferase C; alpha(1,2)FT 2; alpha1,2-fucosyltransferase b; fucosyltransferase 2 (secretor status included); galactoside 2-alpha-L-fucosyltransferase 2; secretor blood group alpha-2-fucosyltransferase; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2

NP_113823.1

EC 2.4.1.344

EC 2.4.1.69

XP_038944697.1

EC 2.4.1.344

EC 2.4.1.69

XP_063128208.1

EC 2.4.1.344

EC 2.4.1.69

XP_063128215.1

EC 2.4.1.344

EC 2.4.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.