Cask calcium/calmodulin dependent serine protein kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Caskprovided by RGD
Full Name: calcium/calmodulin dependent serine protein kinaseprovided by RGD
Primary source: RGD:62004
See related: EnsemblRapid:ENSRNOG00000060946 AllianceGenome:RGD:62004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables PDZ domain binding activity; neurexin family protein binding activity; and protein kinase C binding activity. Involved in several processes, including positive regulation of dendritic spine morphogenesis; positive regulation of insulin secretion; and protein localization to plasma membrane. Located in several cellular components, including apical dendrite; basolateral plasma membrane; and podocyte foot. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 149.8), Adrenal (RPKM 92.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (11572328..11915831)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (8899500..9243014)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (9815652..10156155)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CASK, APBA1, and STXBP1 collaborate during insulin secretion.
Title: CASK, APBA1, and STXBP1 collaborate during insulin secretion.
Structural Basis for the High-Affinity Interaction between CASK and Mint1.
Title: Structural Basis for the High-Affinity Interaction between CASK and Mint1.
induction of beta cell insulin-secretion defects by fatty acids is mediated, at least in part, by FOXO1 via downregulation of Cask expression
Title: Forkhead box O1 mediates defects in palmitate-induced insulin granule exocytosis by downregulation of calcium/calmodulin-dependent serine protein kinase expression in INS-1 cells.
Data suggest that Y-P30 can control the nuclear localization of Calcium/calmodulin-dependent serine kinase (CASK) in a syndecan (SDC) -2 and -3 -dependent manner.
Title: Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.
The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane.
Title: Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.
Our study suggests that the stimulation of beta-cell insulin secretion by Ex-4 is mediated, at least in part, by CASK via a novel signaling mechanism.
Title: Calcium/calmodulin-dependent serine protein kinase is involved in exendin-4-induced insulin secretion in INS-1 cells.
Depletion of liprin-alpha2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-alpha2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release.
Title: Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation.
Title: Post-translational modification of CASK leads to its proteasome-dependent degradation.
Our data demonstrate that the retention and trafficking of NMDARs in this endoplasmic reticulum subcompartment requires both CASK and SAP97.
Title: SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.
The Tbr-1-CASK-CINAP complex regulates expression of NR2b;a Thr-to-Ala point mutation in CASK affects NR2b promoter activity.
Title: CASK point mutation regulates protein-protein interactions and NR2b promoter activity.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXRat48 (e-PCR), detects polymorphism
- UniSTS:228430

RH144070 (e-PCR)
- UniSTS:233316

BF404609 (e-PCR)
- UniSTS:247148

DXGot4 (e-PCR)
- UniSTS:112749

Cask (e-PCR), detects polymorphism
- UniSTS:527276

AU049649 (e-PCR)
- UniSTS:146095

Cask (e-PCR), detects polymorphism
- UniSTS:256961

UniSTS:256965 (e-PCR)
- UniSTS:256965

Cask (e-PCR), detects polymorphism
- UniSTS:256965

Cask (e-PCR), detects polymorphism
- UniSTS:256966

Cask (e-PCR), detects polymorphism
- UniSTS:548054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurexin family protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in podocyte foot	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peripheral plasma membrane protein CASK

Names: calcium/calmodulin-dependent serine protein kinase (MAGUK family); peripheral plasma membrane protein CASK-like

XP_038955486.1

EC 2.7.11.1

XP_038955487.1

EC 2.7.11.1

XP_038955488.1

EC 2.7.11.1

XP_038955489.1

EC 2.7.11.1

XP_038955490.1

EC 2.7.11.1

XP_038955491.1

EC 2.7.11.1

XP_038955492.1

EC 2.7.11.1

XP_038955493.1

EC 2.7.11.1

XP_038955494.1

EC 2.7.11.1

XP_038955495.1

EC 2.7.11.1

XP_063135934.1

EC 2.7.11.1

XP_063135935.1

EC 2.7.11.1

XP_063135937.1

EC 2.7.11.1

XP_063135938.1

EC 2.7.11.1

XP_063135939.1

EC 2.7.11.1

XP_063135940.1

EC 2.7.11.1

XP_063135941.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431578.1 → NP_001418507.1 peripheral plasma membrane protein CASK isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001431579.1 → NP_001418508.1 peripheral plasma membrane protein CASK isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_022184.2 → NP_071520.2 peripheral plasma membrane protein CASK isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K2L8

Related

ENSRNOP00000072295.2, ENSRNOT00000091382.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

11572328..11915831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279864.1 → XP_063135934.1 peripheral plasma membrane protein CASK isoform X2
XM_039099558.2 → XP_038955486.1 peripheral plasma membrane protein CASK isoform X1

UniProtKB/TrEMBL

A6JZX5

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:622 → 683

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:744 → 917

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_039099563.2 → XP_038955491.1 peripheral plasma membrane protein CASK isoform X7

UniProtKB/TrEMBL

A6JZX5

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:732 → 905

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_063279869.1 → XP_063135939.1 peripheral plasma membrane protein CASK isoform X14
XM_063279867.1 → XP_063135937.1 peripheral plasma membrane protein CASK isoform X10

Related

ENSRNOP00000095774.2, ENSRNOT00000099608.2
XM_039099560.2 → XP_038955488.1 peripheral plasma membrane protein CASK isoform X4

UniProtKB/TrEMBL

A6JZX5

Related

ENSRNOP00000096945.2, ENSRNOT00000097626.2

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:738 → 911

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_063279865.1 → XP_063135935.1 peripheral plasma membrane protein CASK isoform X8
XM_039099561.2 → XP_038955489.1 peripheral plasma membrane protein CASK isoform X5

UniProtKB/Swiss-Prot

Q62915

UniProtKB/TrEMBL

A0A8I6GLU3

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:733 → 906

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_039099564.2 → XP_038955492.1 peripheral plasma membrane protein CASK isoform X9

UniProtKB/TrEMBL

A0A8I6APQ1

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:599 → 660

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:721 → 894

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_039099559.2 → XP_038955487.1 peripheral plasma membrane protein CASK isoform X3

UniProtKB/TrEMBL

A6JZX4, A6JZX5

Related

ENSRNOP00000004187.8, ENSRNOT00000004187.8

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:738 → 911

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_063279868.1 → XP_063135938.1 peripheral plasma membrane protein CASK isoform X11
XM_039099565.2 → XP_038955493.1 peripheral plasma membrane protein CASK isoform X12

UniProtKB/TrEMBL

A0A8I6APQ1

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:593 → 654

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:710 → 883

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_039099562.2 → XP_038955490.1 peripheral plasma membrane protein CASK isoform X6

UniProtKB/TrEMBL

A6JZX5, D4A8M2

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:732 → 905

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain
XM_039099567.2 → XP_038955495.1 peripheral plasma membrane protein CASK isoform X17

UniProtKB/TrEMBL

A6JZX6

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:575 → 636

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:692 → 865

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain
XM_063279870.1 → XP_063135940.1 peripheral plasma membrane protein CASK isoform X15
XM_063279871.1 → XP_063135941.1 peripheral plasma membrane protein CASK isoform X16

UniProtKB/TrEMBL

A0A0G2K8F4

Related

ENSRNOP00000074587.2, ENSRNOT00000082316.3
XM_039099566.2 → XP_038955494.1 peripheral plasma membrane protein CASK isoform X13

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:587 → 648

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:709 → 882

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain