Lrpap1 LDL receptor related protein associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrpap1provided by RGD
Official Full Name: LDL receptor related protein associated protein 1provided by RGD
Primary source: RGD:620700
See related: EnsemblRapid:ENSRNOG00000009313 AllianceGenome:RGD:620700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lipase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Located in rough endoplasmic reticulum lumen and vesicle. Used to study membranous glomerulonephritis. Biomarker of membranous glomerulonephritis. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 2281.2), Brain (RPKM 271.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (79876002..79888011)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (75651371..75663380)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (80911281..80923290)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAP binds to LPL with high affinity both in purified systems and cell extracts and RAP-deficient adipocytes secrete poorly assembled LPL
Title: Interaction of lipoprotein lipase and receptor-associated protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1329 (e-PCR)
- UniSTS:32813

RH132960 (e-PCR)
- UniSTS:216243

AI790446 (e-PCR)
- UniSTS:179156

BI281742 (e-PCR)
- UniSTS:249569

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables lipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables low-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables very-low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance by transcytosis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi lumen	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome lumen	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in rough endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-2-macroglobulin receptor-associated protein

Names: RAP; alpha-2-MRAP; gp330-binding 45 kDa protein; low density lipoprotein receptor-related protein-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169113.1 → NP_001162584.1 alpha-2-macroglobulin receptor-associated protein precursor

See identical proteins and their annotated locations for NP_001162584.1

Status: VALIDATED

Source sequence(s)

BC098947, FM055449, M31051

UniProtKB/Swiss-Prot

Q4FZX8, Q642A1, Q64723, Q99068

UniProtKB/TrEMBL

A6IK06

Related

ENSRNOP00000012665.5, ENSRNOT00000012665.7

Conserved Domains (5) summary

cd14806
Location:61 → 70

RAP_D1; 3-helical coiled coil [structural motif]

cd14807
Location:149 → 246

RAP_D2; Domain 2 of receptor-associated protein (RAP)

cd14808
Location:255 → 360

RAP_D3; C-terminal receptor-associated protein (RAP), Domain 3

pfam06400
Location:31 → 134

Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain

pfam06401
Location:149 → 360

Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain