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    Lsamp limbic system-associated membrane protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsampprovided by RGD
    Official Full Name
    limbic system-associated membrane proteinprovided by RGD
    Primary source
    RGD:71102
    See related
    EnsemblRapid:ENSRNOG00000031852 AllianceGenome:RGD:71102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cell adhesion. Predicted to act upstream of or within locomotory exploration behavior. Is active in postsynaptic membrane and presynaptic membrane. Orthologous to human LSAMP (limbic system associated membrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 356.2), Heart (RPKM 127.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lsamp in Genome Data Viewer
    Location:
    11q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (72053285..74223019, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (58547533..60717328, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (58795884..59442772, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481071 Neighboring gene growth associated protein 43 Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC108352336 Neighboring gene large ribosomal subunit protein uL6-like Neighboring gene uncharacterized LOC134481073 Neighboring gene peptidylprolyl isomerase D, pseudogene 8 Neighboring gene uncharacterized LOC134481004 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rats with low exploratory activity in the elevated plus-maze have the increased expression of limbic system-associated membrane protein gene in the periaqueductal grey. Nelovkov A, et al. Neurosci Lett, 2003 Dec 11. PMID 14625014
    2. The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting. Pimenta AF, et al. Neuron, 1995 Aug. PMID 7646886
    3. Isolation, biochemical characterization and ultrastructural analysis of the limbic system-associated membrane protein (LAMP), a protein expressed by neurons comprising functional neural circuits. Zacco A, et al. J Neurosci, 1990 Jan. PMID 1688937, Free PMC Article
    4. Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments. Catania EH, et al. Behav Brain Res, 2008 Apr 9. PMID 18199495, Free PMC Article
    5. Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene. Pimenta AF, et al. Genomics, 2004 May. PMID 15081109

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurotrimin and LSAMP were identified as ADAM10 substrates that are shed from the cell surface of dorsal root ganglion (DRGs) neurons. Overexpression of LSAMP and NTM suppresses outgrowth from DRG neurons.
      Title: Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.
    2. It is likely that LSAMP plays a role in the regulation of exploratory behavior of rats in the novel aversive environment.
      Title: Rats with low exploratory activity in the elevated plus-maze have the increased expression of limbic system-associated membrane protein gene in the periaqueductal grey.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105298

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within locomotory exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    limbic system-associated membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414997.1 → NP_001401926.1  limbic system-associated membrane protein isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0H2UHW7

    2. NM_017242.3 → NP_058938.1  limbic system-associated membrane protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_058938.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q62813, Q6VUH9
      UniProtKB/TrEMBL
      A0A8I5ZZN4, A6IR42
      Related
      ENSRNOP00000100586.1, ENSRNOT00000154067.1
      Conserved Domains (3) summary
      pfam13927
      Location:218 → 294
      Ig_3; Immunoglobulin domain
      cd00096
      Location:235 → 239
      Ig; Ig strand B [structural motif]
      cl11960
      Location:38 → 128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      72053285..74223019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088255.2 → XP_038944183.1  limbic system-associated membrane protein isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHY3, A0A8I5ZZN4
      Conserved Domains (3) summary
      pfam13927
      Location:235 → 311
      Ig_3; Immunoglobulin domain
      cd00096
      Location:252 → 256
      Ig; Ig strand B [structural motif]
      cl11960
      Location:55 → 145
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62813.1 GenPept UniProtKB/Swiss-Prot:Q62813

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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