Tyms thymidylate synthetase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tymsprovided by RGD
Official Full Name: thymidylate synthetaseprovided by RGD
Primary source: RGD:3921
See related: EnsemblRapid:ENSRNOG00000037225 AllianceGenome:RGD:3921
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including folic acid binding activity; protein homodimerization activity; and thymidylate synthase activity. Involved in several processes, including dTMP biosynthetic process; intestinal epithelial cell maturation; and liver regeneration. Predicted to be located in mitochondrial inner membrane; mitochondrial matrix; and nucleus. Predicted to be active in cytosol and mitochondrion. Used to study urinary bladder cancer. Biomarker of colorectal adenocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 144.9), Spleen (RPKM 129.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q38

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (120760057..120776149, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (113313454..113329551, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (121918875..121931564, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables folic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA regulatory element binding translation repressor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables thymidylate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables thymidylate synthase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cartilage development	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in dTMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dTTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in developmental growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in intestinal epithelial cell maturation	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to folic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organophosphorus	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in tetrahydrofolate interconversion	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in uracil metabolic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: thymidylate synthase

Names: TS; TSase

NP_062052.1

EC 2.1.1.45

XP_008765643.1

EC 2.1.1.45

XP_063122880.1

EC 2.1.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.