Oprm1 opioid receptor, mu 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oprm1provided by RGD
Official Full Name: opioid receptor, mu 1provided by RGD
Primary source: RGD:3234
See related: EnsemblRapid:ENSRNOG00000018191 AllianceGenome:RGD:3234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MORA; Oprm; Oprrm1
Summary: Enables several functions, including G-protein beta-subunit binding activity; morphine receptor activity; and voltage-gated calcium channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway; estrous cycle; and regulation of signal transduction. Located in several cellular components, including dendrite; focal adhesion; and perikaryon. Is active in postsynaptic membrane; presynaptic membrane; and spine apparatus. Used to study obesity. Biomarker of brain ischemia; extrahepatic cholestasis; human immunodeficiency virus infectious disease; obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Orthologous to human OPRM1 (opioid receptor mu 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 21.8), Thymus (RPKM 3.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (45565371..45818722)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (43160057..43413409)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (43454803..43704948)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accumbal mu-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics.
Title: Accumbal μ-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics.
Phosphorylated Upstream Frameshift 1-dependent Nonsense-mediated mu-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia-like Behavior in Rats.
Title: Phosphorylated Upstream Frameshift 1-dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia-like Behavior in Rats.
N[6]-Methyladenosine methylase METTL3 contributes to neuropathic pain by epigenetic silencing of mu opioid receptor.
Title: N(6)-Methyladenosine methylase METTL3 contributes to neuropathic pain by epigenetic silencing of mu opioid receptor.
Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
Title: Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
The blockade of muopioid receptors in the lateral hypothalamus enhances panic attacklike behaviour and diminishes defensive antinociception.
Title: The blockade of μ‑opioid receptors in the lateral hypothalamus enhances panic attack‑like behaviour and diminishes defensive antinociception.
Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats.
Title: Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats.
Aversive Stress Reduces Mu Opioid Receptor Expression in the Intercalated Nuclei of the Rat Amygdala.
Title: Aversive Stress Reduces Mu Opioid Receptor Expression in the Intercalated Nuclei of the Rat Amygdala.
Lateral septum mu opioid receptors in stimulation of feeding.
Title: Lateral septum mu opioid receptors in stimulation of feeding.
Role of mu-opioid receptor in nociceptive modulation in anterior cingulate cortex of rats.
Title: Role of mu-opioid receptor in nociceptive modulation in anterior cingulate cortex of rats.
Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.
Title: Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.

Submit: New GeneRIF Correction See all GeneRIFs (140)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94842 (e-PCR)
- UniSTS:120088

RH94843 (e-PCR)
- UniSTS:120089

BF390122 (e-PCR)
- UniSTS:249389

D10Chm38 (e-PCR)
- UniSTS:518216

d1rat136 (e-PCR)
- UniSTS:121454

U19380 (e-PCR)
- UniSTS:159948

D1Arb7 (e-PCR)
- UniSTS:239332

RH142407 (e-PCR)
- UniSTS:231654

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-endorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-endorphin receptor activity	IEA Inferred from Electronic Annotation more info
enables beta-endorphin receptor activity	ISO Inferred from Sequence Orthology more info
enables morphine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables morphine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables morphine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in acute inflammatory response to antigenic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to morphine	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt protein secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm ejaculation	IDA Inferred from Direct Assay more info	PubMed
involved_in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in spine apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mu-type opioid receptor

Names: M-OR-1; MOR-1; MUOR1; opioid receptor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038597.2 → NP_001033686.1 mu-type opioid receptor isoform IA

See identical proteins and their annotated locations for NP_001033686.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1A) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant MOR-1C2. This results in a novel 3' coding region and 3' UTR, compared to variant MOR-1B2. It encodes isoform 1A which is longer/shorter and has a distinct C-terminus, compared to isoform 1C2.

Source sequence(s)

AY309000, L13069

UniProtKB/TrEMBL

B8Q1M0

Related

ENSRNOP00000085499.2, ENSRNOT00000088253.3

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001038599.2 → NP_001033688.2 mu-type opioid receptor isoform 1B2

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1B2) lacks several exons and contains an alternate terminal exon compared to variant MOR-1C2. The encoded isoform (1B2) is shorter than isoform 1C2.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

B8Q1M0

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001038600.2 → NP_001033689.1 mu-type opioid receptor isoform 1C1

See identical proteins and their annotated locations for NP_001033689.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1C1) lacks an alternate segment in the 3' region, compared to variant MOR-1C2. It encodes isoform 1C1 which has is shorter than isoform 1C2.

Source sequence(s)

AY225402, L13069

UniProtKB/TrEMBL

A0A8L2QEH9

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001038601.2 → NP_001033690.1 mu-type opioid receptor isoform 1C2

See identical proteins and their annotated locations for NP_001033690.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1C2) encodes the longest isoform (1C2).

Source sequence(s)

AY225403, L13069

UniProtKB/TrEMBL

A0A8I5ZZ23

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304733.1 → NP_001291662.1 mu-type opioid receptor isoform 1G1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1G1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1G1) is shorter than isoform 1C2.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

B8K2Q4

Conserved Domains (2) summary

pfam00001
Location:1 → 238

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:56 → 183

7tm_4; Olfactory receptor
NM_001304734.1 → NP_001291663.1 mu-type opioid receptor isoform 1G2

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1G2) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1G2) is shorter than isoform 1C2.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D2CKI4

Related

ENSRNOP00000074079.3, ENSRNOT00000083308.3

Conserved Domains (2) summary

pfam00001
Location:7 → 248

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:9 → 193

7tm_4; Olfactory receptor
NM_001304735.1 → NP_001291664.1 mu-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_001291664.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1H1) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P33535, Q2TV20, Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120

UniProtKB/TrEMBL

A6KIP5, B8Q1M0

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304736.1 → NP_001291665.1 mu-type opioid receptor isoform 1H2

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1H2) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1H2) is shorter than isoform 1C2.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D2CKI5

Conserved Domains (2) summary

pfam00001
Location:135 → 386

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:127 → 331

7tm_4; Olfactory receptor
NM_001304737.1 → NP_001291666.1 mu-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_001291666.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1i1) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P33535, Q2TV20, Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120

UniProtKB/TrEMBL

A6KIP5, B8Q1M0

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304738.1 → NP_001291667.1 mu-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_001291667.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1i2) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P33535, Q2TV20, Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120

UniProtKB/TrEMBL

A6KIP5, B8Q1M0

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304740.1 → NP_001291669.1 mu-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_001291669.1

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1i3) represents use of an alternate promoter and 5' UTR, and uses an alternate 3' exon, compared to variant MOR-1C2. The resulting isoform (1) is shorter than isoform 1C2. Variants MOR-1H1, MOR-1i1, MOR-1i2 and MOR-1i3 encode the same isoform.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P33535, Q2TV20, Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120

UniProtKB/TrEMBL

A6KIP5, B8Q1M0

Related

ENSRNOP00000024682.8, ENSRNOT00000024682.10

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_013071.2 → NP_037203.1 mu-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_037203.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks several exons and contains an alternate terminal exon compared to variant MOR-1C2. The encoded isoform (1) is shorter than isoform 1C2.

Source sequence(s)

L13069, L20684

UniProtKB/Swiss-Prot

P33535, Q2TV20, Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120

UniProtKB/TrEMBL

A6KIP5, B8Q1M0

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor

RNA

NR_027877.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (MOR-1D) uses an alternate 3' exon structure, compared to variant MOR-1C2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AY225402, AY309002, L13069