Adrb3 adrenoceptor beta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adrb3provided by RGD
Official Full Name: adrenoceptor beta 3provided by RGD
Primary source: RGD:2061
See related: EnsemblRapid:ENSRNOG00000012674 AllianceGenome:RGD:2061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ADRB
Summary: Enables epinephrine binding activity and norepinephrine binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and eating behavior. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of colitis; congestive heart failure; and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 47.1), Thymus (RPKM 41.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (71544603..71547410)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (64839820..64844552)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (69003541..69006632)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ENDOGENOUS beta 3 -ADRENERGIC RECEPTOR ACTIVATION ALLEVIATES SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT SIGNALING PATHWAY.
Title: ENDOGENOUS β 3 -ADRENERGIC RECEPTOR ACTIVATION ALLEVIATES SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT SIGNALING PATHWAY.
Blocking brown adipocyte beta3-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress.
Title: Blocking brown adipocyte β(3)-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress.
beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Title: β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Present data can emphasize the important deleterious effect of beta3 -AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between beta3 -AR activation, NO-signaling, and [Zn(2+) ]i pathways.
Title: β(3) -adrenergic receptor activation plays an important role in the depressed myocardial contractility via both elevated levels of cellular free Zn(2+) and reactive nitrogen species.
Voluntary exercise induced opposite changes in the gene expression of beta3-adrenergic receptors in the white and in the brown adipose tissue.
Title: Opposite Effects of Voluntary Physical Exercise on β3-Adrenergic Receptors in the White and Brown Adipose Tissue.
In heart failure, the expression of cardiac beta3-adrenergic receptors (beta3-ARs) increases. However, the precise role of beta3-AR signaling within cardiomyocytes remains unclear. The beta3-AR activation in cardiomyocytes increases the expression of TGFbeta1 via the PKG/JNK/c-Jun pathway.
Title: β(3)-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway.
Study demonstrates that MRI allows a precocious detection of the subtle myocardial dysfunction induced by beta1-adrenoreceptors-autoantibodies (beta1-aabs) and that beta3-adrenoreceptor stimulation blunts the development of beta1-aabs-induced dilated cardiomyopathy.
Title: MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.
Increasing beta3-AR stimulation may prevent the consequences of chronic NA exposure on Na(+)/K(+) pump and in vivo hemodynamics. beta3-AR agonism may thus represent a new therapeutic strategy for pharmacological modulation of hypertrophy under conditions of chronically enhanced sympathetic activity.
Title: Role of the β(3)-adrenergic receptor subtype in catecholamine-induced myocardial remodeling.
After 16 h of lipopolysaccharide treatment, cultured neonatal cardiomyocytes showed a diminished Ca2+ transient amplitude associated with an increase in the beta3-AR level.
Title: The Trend of β3-Adrenergic Receptor in the Development of Septic Myocardial Depression: A Lipopolysaccharide-Induced Rat Septic Shock Model.
role of beta2- and beta3-adrenoceptors in arterial stiffness in a state of hypertension
Title: Role of β(2-) and β(3)-adrenoceptors in arterial stiffness in a state of hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (50)

General gene information

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Markers

UniSTS:471071 (e-PCR)
- UniSTS:471071

Adrb3 (e-PCR), detects polymorphism
- UniSTS:471071

PMC164531P1 (e-PCR)
- UniSTS:271495

RH94766 (e-PCR)
- UniSTS:120013

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-3 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables beta-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta3-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta3-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables beta3-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables norepinephrine binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to norepinephrine binding	ISO Inferred from Sequence Orthology more info
contributes_to norepinephrine binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heat generation	ISO Inferred from Sequence Orthology more info
NOT involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: beta-3 adrenergic receptor

Names: adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013108.2 → NP_037240.2 beta-3 adrenergic receptor

See identical proteins and their annotated locations for NP_037240.2

Status: VALIDATED

Source sequence(s)

BQ189922, JAXUCZ010000016, M74716

UniProtKB/Swiss-Prot

P26255

UniProtKB/TrEMBL

A6IVX3

Related

ENSRNOP00000016907.3, ENSRNOT00000016907.4

Conserved Domains (2) summary

pfam00001
Location:51 → 343

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:51 → 145

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

71544603..71547410

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771315.4 → XP_008769537.1 beta-3 adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_008769537.1

UniProtKB/TrEMBL

A6IVX2, A6IVX3

Conserved Domains (2) summary

pfam00001
Location:72 → 364

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:72 → 166

7tm_4; Olfactory receptor