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    S1pr5 sphingosine-1-phosphate receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    S1pr5provided by RGD
    Official Full Name
    sphingosine-1-phosphate receptor 5provided by RGD
    Primary source
    RGD:620566
    See related
    EnsemblRapid:ENSRNOG00000020901 AllianceGenome:RGD:620566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edg8; Edg-8
    Summary
    Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 55.0), Lung (RPKM 18.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See S1pr5 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28062841..28068013, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19786676..19791862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22268635..22273708, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4A Neighboring gene uncharacterized LOC134480144 Neighboring gene Kelch-like ECH-associated protein 1 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung. Chiyo M, et al. Am J Transplant, 2008 Mar. PMID 18294150
    2. Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS. Terai K, et al. Neuroscience, 2003. PMID 12617946
    3. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Glickman M, et al. Mol Cell Neurosci, 1999 Aug. PMID 10532805
    4. Expression of a novel sphingosine 1-phosphate receptor motif protein gene in maturing rat testes. Khalid AM, et al. Biosci Biotechnol Biochem, 2012. PMID 22972346
    5. Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Jolly PS, et al. Blood, 2005 Jun 15. PMID 15741218, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The LOC290876-encoded gene product (EDG-8) has distinct roles in the nucleus during the processes of spermatocyte maturation and spermatid production in meiosis.
      Title: Expression of a novel sphingosine 1-phosphate receptor motif protein gene in maturing rat testes.
    2. These data demonstrate novel roles of S1P(1R,) which include regulating emigration and modulating lymphocyte activation.
      Title: Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung.
    3. Edg8 receptors are preferentially expressed in oligodendrocyte lineage cells including oligodendrocyte progenitor cells and immature oligodendrocytes in rat CNS, and may have important functions in oligodendrocytic maturation and myelination.
      Title: Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS.
    4. The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
      Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
    5. differences between hS1P(5) and rS1P(5) will be an important point to be considered in the development of selective receptor antagonists.
      Title: Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.
    6. SphK1 has a role in regulating degranulation and motility of rat mast cells by desensitizing S1P receptors
      Title: Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
    7. Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.
      Title: Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sphingosine-1-phosphate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine 1-phosphate receptor 5
    Names
    NRG-1
    S1P receptor 5
    S1P receptor Edg-8
    S1P5
    endothelial differentiation G-protein-coupled receptor 8
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
    nerve growth factor-regulated G-protein-coupled receptor 1
    sphingosine 1-phosphate receptor Edg-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021775.2 → NP_068543.2  sphingosine 1-phosphate receptor 5

      See identical proteins and their annotated locations for NP_068543.2

      Status: PROVISIONAL

      Source sequence(s)
      AF115249
      UniProtKB/Swiss-Prot
      Q9JKM5
      Related
      ENSRNOP00000090421.1, ENSRNOT00000098087.2
      Conserved Domains (1) summary
      pfam00001
      Location:53 → 307
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28062841..28068013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242663.5 → XP_006242725.1  sphingosine 1-phosphate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006242725.1

      UniProtKB/Swiss-Prot
      Q9JKM5, Q9QY79
      UniProtKB/TrEMBL
      A6JNQ5
      Related
      ENSRNOP00000101555.1, ENSRNOT00000155578.1
      Conserved Domains (2) summary
      cd14964
      Location:38 → 64
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37 → 318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006242665.5 → XP_006242727.1  sphingosine 1-phosphate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006242727.1

      UniProtKB/Swiss-Prot
      Q9JKM5, Q9QY79
      UniProtKB/TrEMBL
      A6JNQ5
      Related
      ENSRNOP00000028380.3, ENSRNOT00000028380.7
      Conserved Domains (2) summary
      cd14964
      Location:38 → 64
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37 → 318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_006242664.5 → XP_006242726.1  sphingosine 1-phosphate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006242726.1

      UniProtKB/Swiss-Prot
      Q9JKM5, Q9QY79
      UniProtKB/TrEMBL
      A6JNQ5
      Conserved Domains (2) summary
      cd14964
      Location:38 → 64
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37 → 318
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKM5.1 GenPept UniProtKB/Swiss-Prot:Q9JKM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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