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    Tnfrsf8 TNF receptor superfamily member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfrsf8provided by RGD
    Official Full Name
    TNF receptor superfamily member 8provided by RGD
    Primary source
    RGD:3879
    See related
    EnsemblRapid:ENSRNOG00000016782 AllianceGenome:RGD:3879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd30
    Summary
    Predicted to enable protease binding activity. Involved in positive regulation of NF-kappaB transcription factor activity. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 29.4), Lung (RPKM 11.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfrsf8 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (162406387..162451620, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (157123183..157168421, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (163186349..163231578, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene ribosomal protein L36, pseudogene Neighboring gene TNF receptor superfamily member 1B Neighboring gene zinc finger protein 54, pseudogene 1 Neighboring gene reduced expression 2 like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a cDNA for rat CD30 homolog and chromosomal assignment of the genomic gene. Aizawa S, et al. Gene, 1996 Dec 5. PMID 8982082
    2. Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Kurts C, et al. Nature, 1999 Mar 25. PMID 10192335
    3. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. Aizawa S, et al. J Biol Chem, 1997 Jan 24. PMID 8999898
    4. Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3. Nishikori M, et al. Cancer Sci, 2005 Aug. PMID 16108830, Free PMC Article
    5. Expression of the Bcl-2 protein BAD promotes prostate cancer growth. Smith AJ, et al. PLoS One, 2009 Jul 13. PMID 19593445, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TRAIL production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 8
    Names
    CD30L receptor
    Tumor necrosis factor superfamily member 8
    lymphocyte activation antigen CD30
    tumor necrosis factor receptor superfamily, member 8
    tumor necrosis factor superfamily, member CD30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019135.2 → NP_062008.2  tumor necrosis factor receptor superfamily member 8 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      A0A0G2K7Z6, P97525
      UniProtKB/TrEMBL
      A6IU17, F1LNN5
      Related
      ENSRNOP00000022967.5, ENSRNOT00000022968.6
      Conserved Domains (1) summary
      cd13409
      Location:3 → 129
      TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      162406387..162451620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287165.1 → XP_063143235.1  tumor necrosis factor receptor superfamily member 8 isoform X1

      UniProtKB/TrEMBL
      A6IU18
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97525.2 GenPept UniProtKB/Swiss-Prot:P97525

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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