Asip agouti signaling protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asipprovided by RGD
Official Full Name: agouti signaling proteinprovided by RGD
Primary source: RGD:2003
See related: AllianceGenome:RGD:2003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ASP
Summary: This gene is involved in hair pigmentation. In several strains (ACI, IS, LEA, LEC, NER, and WKAH) this gene encodes a functional protein while in others (BN, BUF, DON, F344, SD, SHR, TM, WKY, and WTC) it lacks a 19 nt indel and is non-protein coding. [provided by RefSeq, Apr 2015]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (163933768..164021377)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (143473584..143561170)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (150492010..150579870)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest a possible in-situ mutation of the Asip gene, either within the RrC lineage II population on Okinawa or in an unsampled RrC lineage II population with biogeographic links to Okinawa, although incomplete lineage sorting could not be ruled out.
Title: Potential Causative Mutation for Melanism in Rats Identified in the Agouti Signaling Protein Gene (Asip) of the Rattus rattus Species Complex on Okinawa Island, Japan.
Aggressive offspring is more sensitive to the mother's methyl-containing diet: the percentage of animals that are darker than control rats is higher among aggressive animals than among tame ones
Title: [Methyl-containing diet of mothers affects the AGOUTI gene expression in the offspring of rats with various behavioral types].

Submit: New GeneRIF Correction

General gene information

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Markers

PMC151376P1 (e-PCR)
- UniSTS:271142

RH142058 (e-PCR)
- UniSTS:224048

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables type 3 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 3 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 4 melanocortin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 4 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in epigenetic programming in the zygotic pronuclei	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in generation of precursor metabolites and energy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melanin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: agouti-signaling protein

Names: Agouti (coat color); agouti switch protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052979.2 → NP_443211.1 agouti-signaling protein precursor

See identical proteins and their annotated locations for NP_443211.1

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the protein-coding allele.

Source sequence(s)

AB045587

UniProtKB/Swiss-Prot

Q99JA2

UniProtKB/TrEMBL

F1LQS7

Conserved Domains (1) summary

smart00792
Location:6 → 127

Agouti; Agouti protein

RNA

NR_131764.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) represents the pseudogene allele.

Source sequence(s)

JAXUCZ010000003