Sik1 salt-inducible kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sik1provided by RGD
Official Full Name: salt-inducible kinase 1provided by RGD
Primary source: RGD:69407
See related: EnsemblRapid:ENSRNOG00000001189 AllianceGenome:RGD:69407
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sik; Snf1lk
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in negative regulation of transcription by RNA polymerase II; protein phosphorylation; and regulation of sodium ion transport. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 80.3), Spleen (RPKM 72.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (9947104..9958729, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (9949407..9959036, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (10670747..10680279, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
Title: Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
SIK1 plays a crucial role in the regulation of glucose and lipid metabolism in the livers of HFD/STZ-induced T2DM rats, where it suppresses hepatic gluconeogenesis and lipogenesis by regulating the SIK1/CRTC2 and SIK1/SREBP-1c signalling pathways.
Title: Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization.
Title: The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte.
role for SIK1 in the positive regulation of selective HDL-CE transport function of SR-B1 and steroidogenesis
Title: A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity.
Results show a role of SIK1 in gastrin induced responses and suggest that SIK1 may act as tumour suppressor in gastric adenocarcinoma cells.
Title: Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells.
SIK1 serves as a part of a self-regulatory circuit to modulate insulin secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Title: Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.
these data identify a previously unrecognized mechanism by which SIK1 mediates the activation of MEF2-dependent transcription by BDNF.
Title: Role of salt-inducible kinase 1 in the activation of MEF2-dependent transcription by BDNF.
acute cocaine treatment of rats induced the expression of MEF2C in the striatum via activation of SIK1 and the phosphorylation of HDAC5
Title: Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5.
SIK2 mediates TORC2 inactivation in basal conditions, whereas induction of SIK1 limits transcriptional activation in the hypothalamic paraventricular nucleus
Title: Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats.
These results provide evidence that SIK1 is present in lung epithelial cells and that its function is relevant for the action of isoproterenol during regulation of active sodium transport.
Title: Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anoikis	IEA Inferred from Electronic Annotation more info
involved_in anoikis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in entrainment of circadian clock by photoperiod	IEA Inferred from Electronic Annotation more info
involved_in entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myotube differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase SIK1

Names: SIK-1; SNF1-like kinase; protein kinase KID2; salt-inducible protein kinase 1; serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK

NP_067725.2

EC 2.7.11.1

XP_038954976.1

EC 2.7.11.1

XP_063135557.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021693.3 → NP_067725.2 serine/threonine-protein kinase SIK1

See identical proteins and their annotated locations for NP_067725.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q9R081, Q9R1U5

UniProtKB/TrEMBL

A0A8I6AVK6, A6JK13

Conserved Domains (2) summary

cd14408
Location:300 → 349

UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)

cd14071
Location:26 → 278

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

9947104..9958729 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099048.2 → XP_038954976.1 serine/threonine-protein kinase SIK1 isoform X1

UniProtKB/Swiss-Prot

Q9R081, Q9R1U5

UniProtKB/TrEMBL

A0A8I6AVK6, A6JK13

Related

ENSRNOP00000001579.3, ENSRNOT00000001579.8

Conserved Domains (2) summary

cd14408
Location:300 → 349

UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)

cd14071
Location:26 → 278

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
XM_063279487.1 → XP_063135557.1 serine/threonine-protein kinase SIK1 isoform X2