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    Neu2 Neuroectoderm-expressed 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40375, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neu2provided by FlyBase
    Official Full Name
    Neuroectoderm-expressed 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037085
    Locus tag
    Dmel_CG7204
    See related
    AllianceGenome:FB:FBgn0037085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7204; Dmel\CG7204; neu2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Neu2 in Genome Data Viewer
    Location:
    78D3-78D4; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21484891..21490586, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21477991..21483686, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Syntaxin 7 Neighboring gene crocodile Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined modelling of mRNA decay dynamics and single-molecule imaging in the Drosophila embryo uncovers a role for P-bodies in 5' to 3' degradation. Forbes Beadle L, et al. PLoS Biol, 2023 Jan. PMID 36649329, Free PMC Article
    2. Modeling the cis-regulatory modules of genes expressed in developmental stages of Drosophila melanogaster. López Y, et al. PeerJ, 2017. PMID 28584716, Free PMC Article
    3. Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. Chung HR, et al. EMBO Rep, 2002 Dec. PMID 12446571, Free PMC Article
    4. An RNA-interference screen in Drosophila to identify ZAD-containing C2H2 zinc finger genes that function in female germ cells. Shapiro-Kulnane L, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561227, Free PMC Article
    5. Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Stathopoulos A, et al. Cell, 2002 Nov 27. PMID 12464180

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neuroectoderm-expressed 2
    Names
    CG7204-PA
    CG7204-PB
    Neu2-PA
    Neu2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21484891..21490586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275231.1 → NP_001262160.1  Neuroectoderm-expressed 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFW2
      Conserved Domains (6) summary
      COG5048
      Location:119 → 241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:119 → 141
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:1 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:162 → 185
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:206 → 286
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_141059.3 → NP_649316.1  Neuroectoderm-expressed 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6VQ99, Q0IGS1, Q9VP31
      Related
      FBpp0078048
      Conserved Domains (5) summary
      COG5048
      Location:119 → 241
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:1 → 63
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:162 → 185
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:206 → 286
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6VQ99 B6VQ99
    M9PFW2 M9PFW2

    Gene LinkOut

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