Ren renin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Renprovided by RGD
Official Full Name: reninprovided by RGD
Primary source: RGD:3554
See related: EnsemblRapid:ENSRNOG00000002937 AllianceGenome:RGD:3554
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ren1; RENAA; RATRENAA
Summary: Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including angiotensin maturation; response to cAMP; and response to cGMP. Located in extracellular space. Used to study hypertension. Biomarker of hypertension and primary biliary cholangitis. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 164.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (47348312..47359539)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (44796260..44807491)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (50502724..50513953, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morphology and cyclooxygenase-2 and renin expression in the kidney of young spontaneously hypertensive rats.
Title: Morphology and cyclooxygenase-2 and renin expression in the kidney of young spontaneously hypertensive rats.
Cardiac H9c2 cells overexpressing cyto-renin exhibited enhanced nonmitochondrial oxygen consumption, lactate accumulation, and lactate dehydrogenase activity, reflecting a switch to more aerobic glycolysis known as Warburg effect.
Title: An alternative renin isoform is cardioprotective by modulating mitochondrial metabolism.
Superoxide activates renal Sp3 via lysine acetylation increasing renin activity, AT1R function, and blood pressure in rats.
Title: Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.
Data show that the largest number of contacts was found on chromosome 13, the chromosome with renin gene ( Ren).
Title: Genome-wide map of proximity linkage to renin proximal promoter in rat.
Major components of the renin angiotensin system are located in striatal projection neurons, and striatal astrocytes and microglial cells of rats.
Title: Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells.
The influence of intracellular renin on the inward calcium current in isolated smooth muscle cells from SHR mesenteric arteries was investigated... intracellular renin in vascular resistance vessels from SHR due to internalization or expression, contributes to the regulation of vascular tone and control of peripheral resistance-an effect independently of Ang II.
Title: Intracellular renin increases the inward calcium current in smooth muscle cells of mesenteric artery of SHR. Implications for hypertension and vascular remodeling.
An alternative promoter in intron1 of the renin gene is regulated by glucose starvation via SRF.
Title: An Alternative Promoter in Intron1 of the Renin Gene is Regulated by Glucose Starvation via Serum Response Factor.
renin deficiency leads to significant dysregulation of ion transporters.
Title: Renal sodium transport in renin-deficient Dahl salt-sensitive rats.
Renal ischemia/reperfusion injury induces renin response in the kidney. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain differences in renal vessel regulation between the two genders.
Title: Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.
Isolated perfused hearts obtained from transgenic rats overexpressing cytosolic renin exhibited a 50 % reduction of infarct size after ischemia-reperfusion injury.
Title: Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Wox5 (e-PCR)
- UniSTS:118043

RH138392 (e-PCR)
- UniSTS:220479

D13Arb7 (e-PCR), detects polymorphism
- UniSTS:226498

RH94507 (e-PCR)
- UniSTS:119755

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in angiotensin maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiotensin maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiotensin maturation	ISO Inferred from Sequence Orthology more info
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within drinking behavior	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within establishment of blood-nerve barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in juxtaglomerular apparatus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of blood volume by renin-angiotensin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cGMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: renin

Names: angiotensinogenase; renin 1 structural

NP_036774.4

EC 3.4.23.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012642.4 → NP_036774.4 renin precursor

See identical proteins and their annotated locations for NP_036774.4

Status: PROVISIONAL

Source sequence(s)

BC078878

UniProtKB/Swiss-Prot

P08424, Q63497

UniProtKB/TrEMBL

A6IC75, A6IC76

Related

ENSRNOP00000003951.2, ENSRNOT00000003951.6

Conserved Domains (2) summary

cd05487
Location:76 → 401

renin_like; Renin stimulates production of angiotensin and thus affects blood pressure

pfam07966
Location:31 → 64

A1_Propeptide; A1 Propeptide