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    Ptpn21 protein tyrosine phosphatase, non-receptor type 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171070, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpn21provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 21provided by RGD
    Primary source
    RGD:620216
    See related
    EnsemblRapid:ENSRNOG00000060568 AllianceGenome:RGD:620216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ptp2E
    Summary
    Enables protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 99.0), Kidney (RPKM 65.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn21 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123662783..123727809, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117933066..117998095, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122656500..122721496, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene spermatogenesis associated 7 Neighboring gene uncharacterized LOC134479245 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene EMAP like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway. Cui N, et al. Eur J Pharmacol, 2017 Nov 5. PMID 28843827
    2. Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family. L'Abbé D, et al. FEBS Lett, 1994 Dec 19. PMID 7805871
    3. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Cardone L, et al. Mol Cell Biol, 2004 Jun. PMID 15143158, Free PMC Article
    4. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Bailey MJ, et al. J Biol Chem, 2009 Mar 20. PMID 19103603, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway
      Title: PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.
    2. Expression of Ptpn21 decreases 8-fold at night in the rat pineal gland relative to day values. This appears to reflect negative effects of norepinephrine acting through a cyclic AMP mechanism.
      Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 21
    Names
    protein-tyrosine phosphatase 2E
    NP_598229.2
    XP_017449512.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133545.2 → NP_598229.2  tyrosine-protein phosphatase non-receptor type 21

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q62728, Q62732
      UniProtKB/TrEMBL
      A0A0G2JTB7
      Related
      ENSRNOP00000068645.1, ENSRNOT00000079697.3
      Conserved Domains (4) summary
      smart00295
      Location:24 → 222
      B41; Band 4.1 homologues
      cd13188
      Location:217 → 307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd17192
      Location:20 → 106
      FERM_F1_PTPN21; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and similar proteins
      cl28904
      Location:884 → 1170
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      123662783..123727809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594023.3 → XP_017449512.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      UniProtKB/Swiss-Prot
      Q62728, Q62732
      UniProtKB/TrEMBL
      A0A0G2JTB7
      Conserved Domains (4) summary
      smart00295
      Location:24 → 222
      B41; Band 4.1 homologues
      cd13188
      Location:217 → 307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd17192
      Location:20 → 106
      FERM_F1_PTPN21; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and similar proteins
      cl28904
      Location:884 → 1170
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62728.1 GenPept UniProtKB/Swiss-Prot:Q62728

    Gene LinkOut

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