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    eg eagle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40428, updated on 9-Dec-2024

    Summary

    Official Symbol
    egprovided by FlyBase
    Official Full Name
    eagleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000560
    Locus tag
    Dmel_CG7383
    See related
    AllianceGenome:FB:FBgn0000560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7383; Dmel\CG7383; eag; Eg; egl; Egl; egon; Egon; EGON; NR0A3; spy; T1
    Summary
    Predicted to enable estrogen response element binding activity and nuclear receptor activity. Involved in central nervous system development and regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including CNS glial cell; NB7-3 lineage neurons; neuroblasts; serotonergic neurons; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    78F2-78F3; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21808703..21817600)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21801803..21810700)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Syntrophin-like 1 Neighboring gene long non-coding RNA:CR45958 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin H

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: 21813834-21814131 mobile_element_type = transposon:INE-1{}2105

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    eagle
    Names
    CG7383-PA
    CG7383-PB
    CG7383-PC
    T1 transcription unit
    eg-PA
    eg-PB
    eg-PC
    embryonic gonad
    spready

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21808703..21817600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168938.2NP_730689.1  eagle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730689.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15370, Q0IGS4, Q9VNY0
      UniProtKB/TrEMBL
      H5V893
      Related
      FBpp0078091
      Conserved Domains (1) summary
      cl02596
      Location:387
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    2. NM_079482.4NP_524206.1  eagle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P15370, Q0IGS4, Q9VNY0
      UniProtKB/TrEMBL
      H5V893
      Related
      FBpp0078092
      Conserved Domains (1) summary
      cl02596
      Location:387
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. NM_001275264.1NP_001262193.1  eagle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V893, M9PIJ7
      Conserved Domains (1) summary
      cl02596
      Location:869
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers