Abi1 abl-interactor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abi1provided by RGD
Official Full Name: abl-interactor 1provided by RGD
Primary source: RGD:621008
See related: EnsemblRapid:ENSRNOG00000031325 AllianceGenome:RGD:621008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: E3b1
Summary: Predicted to enable SH3 domain binding activity; protein tyrosine kinase activator activity; and signaling adaptor activity. Involved in postsynapse to nucleus signaling pathway. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 333.4), Spleen (RPKM 310.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (90006917..90088002, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (85098837..85179829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (89951662..90033334)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A functional interplay of a trimeric complex that transforms incoming signals via SK3-channel activation into the local rearrangement of the cytoskeleton in early steps of neuronal differentiation involving nWASP and Abi-1 actin binding proteins.
Title: An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis.
results indicate possible functions of dysbindin-1 at the postsynapse in the regulation of dendritic spine morphogenesis through the interaction with WAVE2 and Abi-1
Title: Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049482 (e-PCR)
- UniSTS:145929

D17Rat51 (e-PCR)
- UniSTS:119329

RH137994 (e-PCR)
- UniSTS:220081

RH127345 (e-PCR)
- UniSTS:210655

AI009242 (e-PCR)
- UniSTS:250605

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within megakaryocyte development	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	EXP Inferred from Experiment more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IEA Inferred from Electronic Annotation more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: abl interactor 1

Names: abelson interactor 1; abi-1; eps8 SH3 domain-binding protein; eps8 binding protein (e3B1), alternatively spliced; eps8-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024397.2 → NP_077373.2 abl interactor 1

See identical proteins and their annotated locations for NP_077373.2

Status: VALIDATED

Source sequence(s)

BC129092, CB725283

UniProtKB/TrEMBL

A2VD09

Related

ENSRNOP00000054381.4, ENSRNOT00000057572.6

Conserved Domains (2) summary

cd11971
Location:423 → 481

SH3_Abi1; Src homology 3 domain of Abl Interactor 1

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

90006917..90088002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096101.2 → XP_038952029.1 abl interactor 1 isoform X6

UniProtKB/TrEMBL

A0A8I6AGM2

Conserved Domains (2) summary

pfam07815
Location:93 → 154

Abi_HHR; Abl-interactor HHR

cl17036
Location:389 → 447

SH3; Src Homology 3 domain superfamily
XM_006254356.5 → XP_006254418.1 abl interactor 1 isoform X4

Related

ENSRNOP00000093871.2, ENSRNOT00000108948.2

Conserved Domains (2) summary

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR

cl17036
Location:394 → 452

SH3; Src Homology 3 domain superfamily
XM_006254359.4 → XP_006254421.1 abl interactor 1 isoform X10

See identical proteins and their annotated locations for XP_006254421.1

Conserved Domains (2) summary

pfam07815
Location:93 → 154

Abi_HHR; Abl-interactor HHR

cl17036
Location:330 → 388

SH3; Src Homology 3 domain superfamily
XM_006254357.5 → XP_006254419.1 abl interactor 1 isoform X7

Conserved Domains (2) summary

pfam07815
Location:93 → 154

Abi_HHR; Abl-interactor HHR

cl17036
Location:388 → 446

SH3; Src Homology 3 domain superfamily
XM_006254355.5 → XP_006254417.1 abl interactor 1 isoform X3

UniProtKB/TrEMBL

A0A8L2UQ93

Conserved Domains (2) summary

cd11971
Location:417 → 475

SH3_Abi1; Src homology 3 domain of Abl Interactor 1

pfam07815
Location:93 → 154

Abi_HHR; Abl-interactor HHR
XM_006254354.5 → XP_006254416.1 abl interactor 1 isoform X2

See identical proteins and their annotated locations for XP_006254416.1

UniProtKB/Swiss-Prot

Q9QZM5

UniProtKB/TrEMBL

A6KRZ5

Related

ENSRNOP00000071079.3, ENSRNOT00000091023.3

Conserved Domains (2) summary

cd11971
Location:418 → 476

SH3_Abi1; Src homology 3 domain of Abl Interactor 1

pfam07815
Location:93 → 154

Abi_HHR; Abl-interactor HHR
XM_006254358.4 → XP_006254420.1 abl interactor 1 isoform X9

See identical proteins and their annotated locations for XP_006254420.1

UniProtKB/TrEMBL

A0A8I5ZQS1

Related

ENSRNOP00000081022.1, ENSRNOT00000093928.2

Conserved Domains (2) summary

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR

cl17036
Location:335 → 393

SH3; Src Homology 3 domain superfamily
XM_006254360.5 → XP_006254422.1 abl interactor 1 isoform X5

Conserved Domains (2) summary

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR

cl17036
Location:393 → 451

SH3; Src Homology 3 domain superfamily
XM_006254353.4 → XP_006254415.1 abl interactor 1 isoform X1

Conserved Domains (2) summary

cd11971
Location:422 → 480

SH3_Abi1; Src homology 3 domain of Abl Interactor 1

pfam07815
Location:93 → 156

Abi_HHR; Abl-interactor HHR
XM_039096103.2 → XP_038952031.1 abl interactor 1 isoform X8

Conserved Domains (2) summary

pfam07815
Location:8 → 71

Abi_HHR; Abl-interactor HHR

cl17036
Location:338 → 396

SH3; Src Homology 3 domain superfamily