Atx-1 Ataxin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atx-1provided by FlyBase
Official Full Name: Ataxin 1provided by FlyBase
Primary source: FLYBASE:FBgn0029907
Locus tag: Dmel_CG4547
See related: AllianceGenome:FB:FBgn0029907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4547; dAtx-1; Dmel\CG4547
Summary: Predicted to enable RNA binding activity. Involved in imaginal disc-derived wing vein specification and photoreceptor cell maintenance. Is expressed in ectoderm and organism. Used to study autosomal dominant cerebellar ataxia. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1. Orthologous to several human genes including ATXN1L (ataxin 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6823204..6824203)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6717237..6718236)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Coiled-coil structure-dependent interactions between ataxin and Foxo lead to dendrite pathology and behavioral defects in a spinocerebellar ataxia model of Drosophila.
Title: Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.
mutant ataxin-1 and huntingtin induce developmental and late-onset neuronal pathologies in Drosophila models
Title: Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models.
Ataxin-1 induces intranuclear accumulation of dAtx2/hAtaxin-2 in both Drosophila and SCA1 postmortem neurons
Title: dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain