Sos Son of sevenless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sosprovided by FlyBase
Official Full Name: Son of sevenlessprovided by FlyBase
Primary source: FLYBASE:FBgn0001965
Locus tag: Dmel_CG7793
See related: AllianceGenome:FB:FBgn0001965
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2.3; 34Ea; BG:DS00941.4; br24; br25; CG7793; dme-SOS; Dmel\CG7793; dSos; E(sev)2A; E(var)189; EC2-5; EK2-8; EY2-3; l(2)34Ea; l(2)br24; l(2)br25; l(2)k05224; l(2)k06321; l(2)Sos; sos; SoS; SOS; Sos1; Su(tor)2-2
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; open tracheal system development; and positive regulation of small GTPase mediated signal transduction. Located in cytosol and rhabdomere microvillus membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including embryonic/larval tracheal section; larval central nervous system; organism subdivision; and spermatozoon. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); atrial heart septal defect; gingival fibromatosis; and pulmonary valve stenosis. Orthologous to several human genes including SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34D1-34D1; 2-49 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13813816..13819824)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13813816..13819826)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos.
Title: Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos.
Disordered proteins mitigate the temperature dependence of site-specific binding free energies.
Title: Disordered proteins mitigate the temperature dependence of site-specific binding free energies.
data support a model in which Robo's ligand-dependent internalization from cell surface to late endosome is essential for receptor activation and proper repulsive guidance at the midline by allowing recruitment of the downstream effector Son of Sevenless
Title: Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion.
identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris
Title: DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.
These results provide in vivo evidence that the Ras and RhoGEF domains of Sos are separable signaling modules and support a model in which Robo recruits Sos to the membrane via Dock to activate Rac during midline repulsion.
Title: Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline.
Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1).
Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.
SosM98, an allele with a single amino acid substitution in the RacGEF motif, functions as a dominant negative in vivo to downregulate receptor tyrosine kinase signaling.
Title: New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon midline choice point recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Ras protein signal transduction	IC Inferred by Curator more info	PubMed
involved_in positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in rhabdomere microvillus membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Son of sevenless

Names: CG7793-PA; Son-of-sevenless; Sos-PA; lethal 24 in the black-reduced region; lethal 25 in the black-reduced region

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13813816..13819824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057249.6 → NP_476597.2 Son of sevenless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476597.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P26675, Q6AWF4, Q8I067, Q8I0F7, Q8ITK2, Q95TI8, Q969D6, Q9VJV9

UniProtKB/TrEMBL

W8NR02

Related

FBpp0080118

Conserved Domains (7) summary

smart00229
Location:637 → 791

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:825 → 1062

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00160
Location:249 → 432

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01261
Location:476 → 586

PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain

pfam00125
Location:90 → 216

Histone; Core histone H2A/H2B/H3/H4

pfam00169
Location:482 → 587

PH; PH domain

cl23907
Location:155 → 196

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...