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    CG11134 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11134provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030518
    Locus tag
    Dmel_CG11134
    See related
    AllianceGenome:FB:FBgn0030518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1; Dmel\CG11134
    Summary
    Predicted to enable methylthioribulose 1-phosphate dehydratase activity and zinc ion binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial tube; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11134 in Genome Data Viewer
    Location:
    12B4-12B4; 1-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13737942..13739177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13631975..13633210)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mutagen-sensitive 101 Neighboring gene garnet Neighboring gene Gamma-tubulin ring protein 91 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization. Barbosa V, et al. Genes Dev, 2000 Dec 15. PMID 11124805, Free PMC Article
    2. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    3. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. Ke H, et al. J Genet Genomics, 2018 Jun 1. PMID 29935791
    4. A misexpression screen to identify regulators of Drosophila larval hemocyte development. Stofanko M, et al. Genetics, 2008 Sep. PMID 18757933, Free PMC Article
    5. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylthioribulose 1-phosphate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylthioribulose 1-phosphate dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11134-PA
    CG11134-PB
    transcript 1
    NP_001259530.1
    NP_572916.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13737942..13739177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272601.1 → NP_001259530.1  uncharacterized protein Dmel_CG11134, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259530.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY93
      UniProtKB/TrEMBL
      M9PEI9
      Conserved Domains (1) summary
      TIGR03328
      Location:18 → 216
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase

    2. NM_132688.4 → NP_572916.1  uncharacterized protein Dmel_CG11134, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY93
      UniProtKB/TrEMBL
      M9PEI9
      Related
      FBpp0073649
      Conserved Domains (1) summary
      TIGR03328
      Location:18 → 216
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEI9 M9PEI9
    Q9VY93.1 Q9VY93

    Gene LinkOut

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