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    Nepl12 Neprilysin-like 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl12provided by FlyBase
    Official Full Name
    Neprilysin-like 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0037727
    Locus tag
    Dmel_CG8358
    See related
    AllianceGenome:FB:FBgn0037727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8358; Dmel\CG8358
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl12 in Genome Data Viewer
    Location:
    85E3-85E3; 3-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9675523..9677778)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5501245..5503500)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Diuretic hormone 44 Neighboring gene Frost Neighboring gene pseudo Neighboring gene Dynein heavy chain 1 Neighboring gene nmdyn-D7 Neighboring gene p23 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New genes in Drosophila quickly become essential. Chen S, et al. Science, 2010 Dec 17. PMID 21164016, Free PMC Article
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis. Lebo MS, et al. BMC Genomics, 2009 Feb 13. PMID 19216785, Free PMC Article
    4. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. Bland ND, et al. BMC Evol Biol, 2008 Jan 23. PMID 18215274, Free PMC Article
    5. Tumour-host interactions through the lens of Drosophila. Bilder D, et al. Nat Rev Cancer, 2021 Nov. PMID 34389815, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 12
    Names
    CG8358-PA
    Nepl12-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9675523..9677778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141667.3 → NP_649924.1  Neprilysin-like 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH96
      Related
      FBpp0081559
      Conserved Domains (1) summary
      cd08662
      Location:68 → 700
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH96 Q9VH96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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