hop hopscotch [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hopprovided by FlyBase
Official Full Name: hopscotchprovided by FlyBase
Primary source: FLYBASE:FBgn0004864
Locus tag: Dmel_CG1594
See related: AllianceGenome:FB:FBgn0004864
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4; CG1594; d-jak; Dm JAK; Dmel\CG1594; DmHD-160; HD-160; Hop; HOP; hop/JAK; Hop1; Hop2; Hpo; jak; Jak; JAK; l(1)10Be; l(1)G18; l(1)hop; l(1)L4; L4; msvl; Tum; Tum-1
Summary: Enables cytokine receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including compound eye morphogenesis; follicle cell of egg chamber development; and imaginal disc morphogenesis. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in adult head; adult mushroom body; organism; and testis. Used to study disease of cellular proliferation and hematologic cancer. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); lung non-small cell carcinoma (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including JAK1 (Janus kinase 1); JAK2 (Janus kinase 2); and JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 10B5-10B6; 1-34 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11360930..11368098, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11254963..11262131, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP. Together, these data constitute a considerable step forward in understanding the role of JAK/STAT signaling in ASPs and similar structures in mammalian models
Title: JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster.
dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis.
Title: JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling.
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK/STAT activation was suppressed by fusion-inducing JNK signaling.
Title: Spatiotemporal regulation of cell fusion by JNK and JAK/STAT signaling during Drosophila wound healing.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms.
Title: A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling.
Data show that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation.
Title: Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.
Our study shows that haemocytes express the three upd genes and that injury markedly induces the expression of upd3 by the JNK pathway in haemocytes, which in turn activates the JAK/STAT pathway in the fat body and the gut. Surprisingly, release of Upd3 from haemocytes upon injury can remotely stimulate stem cell proliferation and the expression of Drosomycin-like genes in the intestine.
Title: Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila.
Hop is a critical component of the piRNA pathway and that it maintains genome integrity by silencing transposons.
Title: Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis.
these data led us to propose that Wdp acts as a novel negative feedback regulator of the JAK/STAT pathway in regulating intestinal homeostasis
Title: Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.
results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.
Title: Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling.
Our work indicates that Slit-Robo signaling affects stem cell function downstream of the JAK-STAT pathway by controlling the ability of stem cells to compete for occupancy in their niche.
Title: Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in equator specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber stalk formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in haltere disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mediolateral intercalation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in periodic partitioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hopscotch

Names: CG1594-PA; Hop; JAK kinase; Janus-family kinase; hop-PA; hopskotch; janus kinase; locus 18; tumorous

NP_511119.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11360930..11368098 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078564.3 → NP_511119.2 hopscotch [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511119.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24592, Q712V3, Q8SZI9, Q9VYZ7

Related

FBpp0073313

Conserved Domains (5) summary

smart00219
Location:894 → 1151

TyrKc; Tyrosine kinase, catalytic domain

cd09921
Location:420 → 516

SH2_Jak_family; Src homology 2 (SH2) domain in the Janus kinase (Jak) family

smart00295
Location:39 → 259

B41; Band 4.1 homologues

cd05037
Location:584 → 836

PTK_Jak_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases

cd05038
Location:886 → 1155

PTKc_Jak_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases