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    xit xiantuan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xitprovided by FlyBase
    Official Full Name
    xiantuanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029906
    Locus tag
    Dmel_CG4542
    See related
    AllianceGenome:FB:FBgn0029906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Alg8; CG4542; dAlg8; Dalg8; Dmel\CG4542; Xit
    Summary
    Predicted to enable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in apical constriction involved in gastrulation; germ-band extension; and protein glycosylation. Located in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See xit in Genome Data Viewer
    Location:
    6D3-6D3; 1-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6821016..6822840)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6715049..6716873)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene inactive Neighboring gene Nuclear factor Y-box C Neighboring gene Ataxin 1 Neighboring gene no-on-and-no-off transient C Neighboring gene muscarinic Acetylcholine Receptor, C-type

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning. Sung HH, et al. Nat Commun, 2024 Aug 27. PMID 39191750, Free PMC Article
    2. Structures and functions of invertebrate glycosylation. Zhu F, et al. Open Biol, 2019 Jan 31. PMID 30958118, Free PMC Article
    3. The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. Shaik KS, et al. Glycobiology, 2011 Jun. PMID 21199819
    4. The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Zhang Y, et al. Dev Biol, 2014 Jun 15. PMID 24681004
    5. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. Xie J, et al. PLoS Genet, 2021 May. PMID 33983927, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The glucosyltransferase Xiantuan (xit, CG4542) of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila.
      Title: The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apical constriction involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in germ-band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    xiantuan
    Names
    CG4542-PA
    xit-PA
    NP_572355.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6821016..6822840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132127.4 → NP_572355.1  xiantuan [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572355.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q058Z6, Q9W3V8
      Related
      FBpp0070931
      Conserved Domains (1) summary
      pfam03155
      Location:12 → 478
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3V8.1 Q9W3V8

    Gene LinkOut

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