C3G C3G guanyl-nucleotide exchange factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: C3Gprovided by FlyBase
Official Full Name: C3G guanyl-nucleotide exchange factorprovided by FlyBase
Primary source: FLYBASE:FBgn0259228
Locus tag: Dmel_CG42328
See related: AllianceGenome:FB:FBgn0259228
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c(3)G; C(3)G; CG14436; CG3126; CG42328; DC3-G; DC3G; Dmel\CG42328
Old locus tag: Dmel_CG14436; Dmel_CG3126
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including Ras protein signal transduction; positive regulation of smoothened signaling pathway; and sarcomere organization. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; gut section; larval central nervous system; somatic mesoderm; and visceral mesoderm. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6D1-6D2; 1-18 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6780790..6803593, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6674823..6697626, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A 213-Amino Acid In-Frame Deletion within the Coiled-Coil Region of C(3)G Impairs the Maintenance of the synaptonemal complex in Early to Mid Pachytene.
Title: X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance.
C3G stimulates guanine nucleotide exchange on Drosophila Rap GTPases in vitro
Title: The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.
the N terminus of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.
Title: The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: C3G guanyl-nucleotide exchange factor

Names: C3G ortholog; C3G-PC; C3G-PD; C3G-PE; C3G-PF; C3G-PG; C3G-PH; C3G-PI; C3G-PJ; C3G-PK; C3G-PL; CG42328-PC; CG42328-PD; CG42328-PE; CG42328-PF; CG42328-PG; CG42328-PH; CG42328-PI; CG42328-PJ; CG42328-PK; CG42328-PL

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6780790..6803593 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298037.1 → NP_001284966.1 C3G guanyl-nucleotide exchange factor, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284966.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JIR4

Conserved Domains (2) summary

smart00229
Location:956 → 1092

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1121 → 1344

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_176694.3 → NP_788867.1 C3G guanyl-nucleotide exchange factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788867.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77086

Related

FBpp0289069

Conserved Domains (2) summary

smart00229
Location:1119 → 1255

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1284 → 1507

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001272362.1 → NP_001259291.1 C3G guanyl-nucleotide exchange factor, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259291.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJ95

Conserved Domains (2) summary

smart00229
Location:1013 → 1149

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1178 → 1401

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144695.3 → NP_001138167.1 C3G guanyl-nucleotide exchange factor, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138167.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z129

Conserved Domains (2) summary

smart00229
Location:1016 → 1152

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1181 → 1404

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001272364.1 → NP_001259293.1 C3G guanyl-nucleotide exchange factor, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259293.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGJ9

Conserved Domains (2) summary

smart00229
Location:1067 → 1203

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1232 → 1455

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144696.3 → NP_001138168.1 C3G guanyl-nucleotide exchange factor, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138168.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z130

Conserved Domains (2) summary

smart00229
Location:1067 → 1203

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1232 → 1455

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144697.2 → NP_001138169.1 C3G guanyl-nucleotide exchange factor, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138169.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z131

Conserved Domains (2) summary

smart00229
Location:833 → 969

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:998 → 1221

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144694.2 → NP_001138166.1 C3G guanyl-nucleotide exchange factor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138166.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z132

Conserved Domains (2) summary

smart00229
Location:884 → 1020

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1049 → 1272

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001272363.1 → NP_001259292.1 C3G guanyl-nucleotide exchange factor, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259292.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z131

Conserved Domains (2) summary

smart00229
Location:833 → 969

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:998 → 1221

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_132122.5 → NP_572350.2 C3G guanyl-nucleotide exchange factor, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572350.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O77086, Q1ECB6, Q7YU30, Q86B63, Q9W3W3

Related

FBpp0289753

Conserved Domains (2) summary

smart00229
Location:1170 → 1306

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1335 → 1558

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...