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    shf shifted [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shfprovided by FlyBase
    Official Full Name
    shiftedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003390
    Locus tag
    Dmel_CG3135
    See related
    AllianceGenome:FB:FBgn0003390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3134; CG3135; CT10514; D-Wif; Dmel\CG3135; DmWif; DmWIF; DWif; Shf; shf-ov
    Summary
    Predicted to enable signaling receptor binding activity. Involved in several processes, including positive regulation of smoothened signaling pathway; protein stabilization; and synaptic target recognition. Located in extracellular matrix and extracellular region. Is expressed in cuboidal/columnar epithelium; embryonic hindgut; embryonic optic lobe primordium; hindgut proper primordium; and posterior spiracle primordium. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See shf in Genome Data Viewer
    Location:
    6C13-6D1; 1-18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6771463..6779659, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6665496..6673692, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44964 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43496 Neighboring gene small ovary Neighboring gene Coenzyme Q7 Neighboring gene C3G guanyl-nucleotide exchange factor Neighboring gene pod1 coronin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative Morphological Variation in the Developing Drosophila Wing. Matamoro-Vidal A, et al. G3 (Bethesda), 2018 Jul 2. PMID 29844017, Free PMC Article
    2. Shifted from Wnt to Hedgehog signaling pathways. Han C, et al. Mol Cell, 2005 Feb 4. PMID 15694333
    3. Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Benner L, et al. Genetics, 2019 Nov. PMID 31558581, Free PMC Article
    4. Hedgehog on track: Long-distant signal transport and transfer through direct cell-to-cell contact. Gradilla AC, et al. Curr Top Dev Biol, 2022. PMID 35817500
    5. The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration. Deshpande G, et al. PLoS Genet, 2013. PMID 24068944, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that production of this PGC attractant depends upon shf as well as a second hh pathway gene g gamma1.
      Title: The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration.
    2. analysis of balancing between hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
      Title: Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.
    3. study concludes that the WIF domain is responsible for the divergence between Drosophila Shf and human Wif-1, channeling the recognition either toward Hh or Wg signal, whereas the EGF repeats give the protein the ability to interact with glypicans
      Title: The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog.
    4. Shifted is a secreted protein that acts over a long distance and is required for the normal accumulation of Hh protein and its movement in the wing.
      Title: Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog.
    5. Shf is the ortholog of the human Wnt inhibitory factor (WIF), a secreted antagonist of the Wingless pathway. Shf is required for Hh stability and for lipid-modified Hh diffusion.
      Title: The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to extracellular region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shifted
    Names
    CG3135-PA
    CG3135-PB
    CG3135-PC
    CG3135-PD
    WNT inhibitory factor
    shf-PA
    shf-PB
    shf-PC
    shf-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6771463..6779659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298035.1 → NP_001284964.1  shifted, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAQ0
      Conserved Domains (1) summary
      pfam02019
      Location:137 → 258
      WIF; WIF domain

    2. NM_001298036.1 → NP_001284965.1  shifted, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCU9
      Conserved Domains (1) summary
      pfam02019
      Location:137 → 258
      WIF; WIF domain

    3. NM_132121.3 → NP_572349.1  shifted, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961F3, Q9W3W5
      Related
      FBpp0070939
      Conserved Domains (1) summary
      pfam02019
      Location:137 → 258
      WIF; WIF domain

    4. NM_001298034.1 → NP_001284963.1  shifted, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JED7
      Conserved Domains (1) summary
      pfam02019
      Location:137 → 258
      WIF; WIF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3W5.2 Q9W3W5
    X2JAQ0 X2JAQ0
    X2JCU9 X2JCU9
    X2JED7 X2JED7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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