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    Tat Tyrosine aminotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tatprovided by FlyBase
    Official Full Name
    Tyrosine aminotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030558
    Locus tag
    Dmel_CG1461
    See related
    AllianceGenome:FB:FBgn0030558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg1461; CG1461; Dmel\CG1461; TAT
    Summary
    Enables L-tyrosine-2-oxoglutarate transaminase activity. Involved in L-phenylalanine catabolic process and tyrosine catabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tat in Genome Data Viewer
    Location:
    12E6-12E6; 1-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14261223..14265379)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14155256..14159412)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46473 Neighboring gene uncharacterized protein Neighboring gene mushroom body defect Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene narrow abdomen Neighboring gene Mucin 12Ea Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in thermodependence of the tyrosine transaminating activity in mitochondria of Drosophila melanogaster larvae due to environmental stress. Rzymkiewicz DM. Int J Biochem, 1990. PMID 1979544
    2. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. Maguire SE, et al. J Biol Chem, 2015 Aug 14. PMID 26124278, Free PMC Article
    3. Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila. Kosakamoto H, et al. Development, 2024 Jan 1. PMID 38165175
    4. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
    5. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-tyrosine-2-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-tyrosine-2-oxoglutarate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-tyrosine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-tyrosine-2-oxoglutarate transaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyrosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine aminotransferase
    Names
    CG1461-PA
    CG1461-PB
    Tat-PA
    Tat-PB
    NP_001285238.1
    NP_572953.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14261223..14265379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298309.1 → NP_001285238.1  tyrosine aminotransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY42
      Conserved Domains (2) summary
      cd00609
      Location:112 → 475
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      TIGR01264
      Location:79 → 481
      tyr_amTase_E; tyrosine aminotransferase, eukaryotic

    2. NM_132725.3 → NP_572953.1  tyrosine aminotransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY42
      Related
      FBpp0073725
      Conserved Domains (2) summary
      cd00609
      Location:112 → 475
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      TIGR01264
      Location:79 → 481
      tyr_amTase_E; tyrosine aminotransferase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY42 Q9VY42

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