U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Alp5 Alkaline phosphatase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42482, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Alp5provided by FlyBase
    Official Full Name
    Alkaline phosphatase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038845
    Locus tag
    Dmel_CG10827
    See related
    AllianceGenome:FB:FBgn0038845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10827; Dmel\CG10827
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in adult head. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Alp5 in Genome Data Viewer
    Location:
    93B3-93B3; 3-70 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21005160..21006990, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16830882..16832712, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Na pump alpha subunit Neighboring gene Na/Ca-exchange protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ral interacting protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. Kühn F, et al. JCI Insight, 2020 Mar 26. PMID 32213701, Free PMC Article
    2. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
    3. Protein-protein interaction network analysis of insecticide resistance molecular mechanism in Drosophila melanogaster. Zhang G, et al. Arch Insect Biochem Physiol, 2019 Jan. PMID 30478906
    4. New components of Drosophila leg development identified through genome wide association studies. Grubbs N, et al. PLoS One, 2013. PMID 23560084, Free PMC Article
    5. Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Yurkevych IS, et al. Biogerontology, 2020 Oct. PMID 32468146

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alkaline phosphatase 5
    Names
    Alp5-PA
    CG10827-PA
    NP_650931.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21005160..21006990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142674.4 → NP_650931.1  alkaline phosphatase 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDG4
      Related
      FBpp0083450
      Conserved Domains (1) summary
      pfam00245
      Location:84 → 514
      Alk_phosphatase; Alkaline phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDG4 Q9VDG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous