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    Or22a Odorant receptor 22a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Or22aprovided by FlyBase
    Official Full Name
    Odorant receptor 22aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026398
    Locus tag
    Dmel_CG12193
    See related
    AllianceGenome:FB:FBgn0026398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    22a; 22A.1; AN11; CG12193; Dmel Or22a; Dmel22a; Dmel\CG12193; DmOr22a; dOr22a; DOR22a; DOR22A.1; dor53; Dor53; DOR53; Or22; OR22a; Or22A.1; Or22a/b; Or53
    Summary
    Enables ionotropic olfactory receptor activity and ligand-gated monoatomic cation channel activity. Involved in monoatomic cation transmembrane transport; olfactory behavior; and sensory perception of smell. Located in dendrite membrane and sensory dendrite. Is expressed in adult olfactory antennal lobe glomerulus; large basiconic sensillum of antennal segment 3; organism subdivision; and sensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Or22a in Genome Data Viewer
    Location:
    22A2-22A2; 2-3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1520491..1522156)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1520491..1522156)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene halo Neighboring gene Odorant receptor 22b Neighboring gene hattifattener Neighboring gene no individualized sperm

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transformation of olfactory representations in the Drosophila antennal lobe. Wilson RI, et al. Science, 2004 Jan 16. PMID 14684826
    2. Activity of Single Insect Olfactory Receptors Triggered by Airborne Compounds Recorded in Self-Assembled Tethered Lipid Bilayer Nanoarchitectures. Kleinheinz D, et al. ACS Appl Mater Interfaces, 2023 Oct 11. PMID 37753951, Free PMC Article
    3. A neonicotinoid pesticide alters Drosophila olfactory processing. Tatarko AR, et al. Sci Rep, 2023 Jun 30. PMID 37391495, Free PMC Article
    4. Odor-induced cAMP production in Drosophila melanogaster olfactory sensory neurons. Miazzi F, et al. J Exp Biol, 2016 Jun 15. PMID 27045092
    5. Predicting Human Olfactory Perception from Activities of Odorant Receptors. Kowalewski J, et al. iScience, 2020 Aug 21. PMID 32731170, Free PMC Article

    See all (169) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intraspecific study of 4 natural populations of D melanogaster survey showed a copy-number polymorphism in some of the populations, with the 2 genes, Or22a & Or22b in the long variant and a single chimeric gene, Or22ab present in the short variant.
      Title: Nucleotide and copy-number polymorphism at the odorant receptor genes Or22a and Or22b in Drosophila melanogaster.
    2. signals by opening cation channels, through a mechanism that is largely independent of G proteins
      Title: Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins.
    3. Data show that Or22a is expressed in approxiamately 25 olfactory sensory neurons and marks a small glomerulus, DM2.
      Title: The olfactory sensory map in Drosophila.
    4. odorant receptors thus form ligand-gated channels as well as complexes of odorant-sensing units and cyclic-nucleotide-activated non-selective cation channels
      Title: Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.
    5. The or22a neuron major projected into glomerulus of DM2 and less projected to VC1 and VC31.
      Title: Olfactory neurons expressing identified receptor genes project to subsets of glomeruli within the antennal lobe of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ionotropic olfactory receptor activity HDA PubMed 
    enables ionotropic olfactory receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ionotropic olfactory receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ligand-gated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables odorant binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception of smell HDA PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of smell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    odorant receptor 22a
    Names
    CG12193-PA
    Or22a-PA
    odorant receptor 53
    olfactory receptor 22A.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1520491..1522156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078729.3 → NP_523453.1  odorant receptor 22a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7VC05, B7VC07, B7VC09, B7VC11, B7VC21, B7VC27, B7VC29, B7VC75, B7VC77, B7VCA5, P81909, Q9U6X7
      UniProtKB/TrEMBL
      I6LU49, I6LU58
      Related
      FBpp0077541
      Conserved Domains (1) summary
      pfam02949
      Location:81 → 381
      7tm_6; 7tm Odorant receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81909.1 P81909

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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