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    RluA-1 RluA pseudouridine synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RluA-1provided by FlyBase
    Official Full Name
    RluA pseudouridine synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0051719
    Locus tag
    Dmel_CG31719
    See related
    AllianceGenome:FB:FBgn0051719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13143; CG31719; CG7475; Dmel\CG31719; RluA1
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in enzyme-directed rRNA pseudouridine synthesis. Is expressed in several structures, including adult central brain; adult optic lobe; dorsal pharyngeal muscle cell; embryonic/larval dorsal vessel; and sensory neurons. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RluA-1 in Genome Data Viewer
    Location:
    31E6-31F1; 2-42 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10463340..10474349, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10463340..10474349, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lysosomal alpha-mannosidase I Neighboring gene Lysosomal alpha-mannosidase II Neighboring gene RluA pseudouridine synthase 2 Neighboring gene Grip75 Neighboring gene Component of oligomeric golgi complex 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Pseudouridine Synthases in the RluA Family Causes Hypersensitive Nociception in Drosophila. Song W, et al. G3 (Bethesda), 2020 Dec 3. PMID 33028630, Free PMC Article
    2. Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1. Wang CC, et al. Int J Dev Biol, 2011. PMID 21671225
    3. Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape. Jinushi-Nakao S, et al. Neuron, 2007 Dec 20. PMID 18093520
    4. Centrosomin represses dendrite branching by orienting microtubule nucleation. Yalgin C, et al. Nat Neurosci, 2015 Oct. PMID 26322925
    5. Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell death. Shimono K, et al. Neural Dev, 2009 Oct 2. PMID 19799768, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in enzyme-directed rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RluA pseudouridine synthase 1
    Names
    CG31719-PA
    CG31719-PB
    CG31719-PC
    CG31719-PD
    RluA-1-PA
    RluA-1-PB
    RluA-1-PC
    RluA-1-PD
    multiple

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10463340..10474349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273422.1 → NP_001260351.1  RluA pseudouridine synthase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCT9
      Conserved Domains (1) summary
      pfam15336
      Location:21 → 162
      Auts2; Autism susceptibility gene 2 protein

    2. NM_164932.2 → NP_723594.1  RluA pseudouridine synthase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P70, Q9VKV0
      Related
      FBpp0079631
      Conserved Domains (2) summary
      cd02557
      Location:363 → 547
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
      pfam15336
      Location:21 → 162
      Auts2; Autism susceptibility gene 2 protein

    3. NM_164930.2 → NP_723592.1  RluA pseudouridine synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P70, Q9VKV0
      Related
      FBpp0079629
      Conserved Domains (2) summary
      cd02557
      Location:363 → 547
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
      pfam15336
      Location:21 → 162
      Auts2; Autism susceptibility gene 2 protein

    4. NM_164931.2 → NP_723593.1  RluA pseudouridine synthase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P70, Q9VKV0
      Related
      FBpp0079630
      Conserved Domains (2) summary
      cd02557
      Location:363 → 547
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
      pfam15336
      Location:21 → 162
      Auts2; Autism susceptibility gene 2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCT9 M9PCT9
    Q86P70 Q86P70
    Q9VKV0 Q9VKV0

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