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    JAK2 Janus kinase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694184, updated on 17-Aug-2024

    Summary

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    Official Symbol
    JAK2provided by VGNC
    Official Full Name
    Janus kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:73811
    See related
    Ensembl:ENSMMUG00000014558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See JAK2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (78701446..78857474, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (79365046..79520546, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene insulin like 4 Neighboring gene insulin like 6 Neighboring gene transcription factor E2-alpha pseudogene Neighboring gene decaprenyl-diphosphate synthase subunit 1 pseudogene Neighboring gene casein kinase I pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene microRNA mir-101-2 Neighboring gene RNA terminal phosphate cyclase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase JAK2
    NP_001252830.1
    XP_028690044.1
    XP_028690045.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265901.2 → NP_001252830.1  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_001252830.1

      Status: PROVISIONAL

      Source sequence(s)
      JU475502
      UniProtKB/TrEMBL
      A0A5F8ATC5, G7NG75
      Related
      ENSMMUP00000081072.1, ENSMMUT00000094777.1
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      78701446..78857474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028834212.1 → XP_028690045.1  tyrosine-protein kinase JAK2 isoform X2

      UniProtKB/TrEMBL
      H9F904
      Conserved Domains (3) summary
      cd05078
      Location:140 → 401
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:439 → 722
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cl15255
      Location:1 → 77
      SH2; Src homology 2 (SH2) domain

    2. XM_028834211.1 → XP_028690044.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A5F8ATC5, G7NG75
      Related
      ENSMMUP00000019119.3, ENSMMUT00000020426.4
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain
    Nucleotide Protein
    Heading Accession and Version

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