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    HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701331, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HECW1provided by VGNC
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:73217
    See related
    Ensembl:ENSMMUG00000019015
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HECW1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (71582792..72042910, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (65158198..65616932, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676927 Neighboring gene cytochrome c oxidase assembly factor 1 Neighboring gene serine/threonine kinase 17a Neighboring gene 60S ribosomal protein L18a pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC114676928 Neighboring gene uncharacterized LOC106997438 Neighboring gene mitochondrial ribosomal protein L32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECW1
    NP_001252739.1
    XP_014989012.1
    XP_014989013.1
    XP_014989015.1
    XP_014989016.1
    XP_014989017.1
    XP_014989018.1
    XP_014989019.1
    XP_014989020.1
    XP_028700694.1
    XP_028700695.1
    XP_028700696.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265810.1 → NP_001252739.1  E3 ubiquitin-protein ligase HECW1

      See identical proteins and their annotated locations for NP_001252739.1

      Status: PROVISIONAL

      Source sequence(s)
      JV565083
      UniProtKB/TrEMBL
      G7MLF3, I2CTY3
      Related
      ENSMMUP00000044831.1, ENSMMUT00000068203.2
      Conserved Domains (4) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:830 → 861
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1250 → 1604
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      71582792..72042910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028844862.1 → XP_028700695.1  E3 ubiquitin-protein ligase HECW1 isoform X4

      UniProtKB/TrEMBL
      G7MLF3, I2CTY3
      Conserved Domains (4) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:830 → 861
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1250 → 1604
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    2. XM_015133533.2 → XP_014989019.1  E3 ubiquitin-protein ligase HECW1 isoform X7

      UniProtKB/TrEMBL
      F6RAK3, G7MLF3
      Related
      ENSMMUP00000025010.3, ENSMMUT00000026729.4
      Conserved Domains (6) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:986 → 1017
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1240 → 1569
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:799 → 827
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    3. XM_015133532.2 → XP_014989018.1  E3 ubiquitin-protein ligase HECW1 isoform X6

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (6) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:987 → 1018
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1241 → 1570
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1217 → 1571
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:800 → 828
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    4. XM_015133527.2 → XP_014989013.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      UniProtKB/TrEMBL
      G7MLF3
      Related
      ENSMMUP00000048757.2, ENSMMUT00000058028.2
      Conserved Domains (5) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:831 → 862
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1275 → 1604
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1251 → 1605
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    5. XM_015133531.2 → XP_014989017.1  E3 ubiquitin-protein ligase HECW1 isoform X5

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (6) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:988 → 1019
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1242 → 1571
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1218 → 1572
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:801 → 829
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    6. XM_015133526.2 → XP_014989012.1  E3 ubiquitin-protein ligase HECW1 isoform X1

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (5) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:832 → 863
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1276 → 1605
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1252 → 1606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    7. XM_015133530.2 → XP_014989016.1  E3 ubiquitin-protein ligase HECW1 isoform X3

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (4) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:831 → 862
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1251 → 1605
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    8. XM_028844861.1 → XP_028700694.1  E3 ubiquitin-protein ligase HECW1 isoform X3

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (4) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:831 → 862
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1251 → 1605
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    9. XM_015133529.2 → XP_014989015.1  E3 ubiquitin-protein ligase HECW1 isoform X3

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (4) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:831 → 862
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1251 → 1605
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    10. XM_028844863.1 → XP_028700696.1  E3 ubiquitin-protein ligase HECW1 isoform X8

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (3) summary
      cd08691
      Location:52 → 188
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:678 → 709
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:1098 → 1452
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    11. XM_015133534.2 → XP_014989020.1  E3 ubiquitin-protein ligase HECW1 isoform X9

      UniProtKB/TrEMBL
      G7MLF3
      Conserved Domains (4) summary
      cd08691
      Location:35 → 171
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:661 → 692
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1105 → 1434
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1081 → 1435
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
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