SOCS3 suppressor of cytokine signaling 3 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SOCS3provided by VGNC
Official Full Name: suppressor of cytokine signaling 3provided by VGNC
Primary source: VGNC:VGNC:77740
See related: Ensembl:ENSMMUG00000058428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	16	NC_041769.1 (74717689..74719374, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	16	NC_027908.1 (72173372..72175061, complement)

Chromosome 16 - NC_041769.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.
Title: Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T cells during acute simian immunodeficiency virus infection.

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General gene information

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Markers

PMC298718P3 (e-PCR)
- UniSTS:272458

PMC298718P4 (e-PCR)
- UniSTS:272459

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: suppressor of cytokine signaling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001194326.2 → NP_001181255.2 suppressor of cytokine signaling 3

Status: PROVISIONAL

Source sequence(s)

QNVO02000164

UniProtKB/TrEMBL

A0A5F7ZL11, A0A8J8Y4P9, F6UUY8, G7NH03

Related

ENSMMUP00000066311.1, ENSMMUT00000097709.1

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03737
Location:184 → 225

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...