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    SNCA synuclein alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706985, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SNCAprovided by VGNC
    Official Full Name
    synuclein alphaprovided by VGNC
    Primary source
    VGNC:VGNC:77668
    Locus tag
    EGK_15919
    See related
    Ensembl:ENSMMUG00000012123
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SNCA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (88118358..88230916, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (88125924..88238817, complement)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene GPRIN family member 3 Neighboring gene multimerin 1 Neighboring gene coiled-coil serine rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. Yang W, et al. J Neurosci, 2015 May 27. PMID 26019347, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.
      Title: Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cuprous ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-synuclein
    Names
    Non-A beta component of AD amyloid
    alpha-synuclein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      88118358..88230916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015138786.2 → XP_014994272.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Related
      ENSMMUP00000068039.1, ENSMMUT00000104822.1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    2. XM_015138787.2 → XP_014994273.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    3. XM_015138791.2 → XP_014994277.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Related
      ENSMMUP00000060035.2, ENSMMUT00000077846.2
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    4. XM_015138789.2 → XP_014994275.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    5. XM_015138785.2 → XP_014994271.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Related
      ENSMMUP00000073855.1, ENSMMUT00000097374.1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    6. XM_015138784.2 → XP_014994270.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    7. XM_028848624.1 → XP_028704457.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    8. XM_015138783.2 → XP_014994269.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Related
      ENSMMUP00000050306.1, ENSMMUT00000061659.2
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    9. XM_028848623.1 → XP_028704456.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    10. XM_028848625.1 → XP_028704458.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    11. XM_015138788.2 → XP_014994274.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    12. XM_015138790.2 → XP_014994276.1  alpha-synuclein isoform X1

      UniProtKB/Swiss-Prot
      P61143
      UniProtKB/TrEMBL
      A0A5F8A5W4, A0A8J8Y4A0, G7MTE2, H9ERB9
      Related
      ENSMMUP00000015893.3, ENSMMUT00000016970.3
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    13. XM_028848626.1 → XP_028704459.1  alpha-synuclein isoform X2

      UniProtKB/TrEMBL
      A0A5F8AED5
      Related
      ENSMMUP00000076291.1, ENSMMUT00000089345.1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61143.1 GenPept UniProtKB/Swiss-Prot:P61143

    Gene LinkOut

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