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    HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710833, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HMGCLprovided by VGNC
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA lyaseprovided by VGNC
    Primary source
    VGNC:VGNC:73483
    See related
    Ensembl:ENSMMUG00000019548
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HMGCL in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (200922420..200964472)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (22596568..22622097, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene cannabinoid receptor 2 Neighboring gene small nucleolar RNA U13 Neighboring gene alpha-L-fucosidase 1 Neighboring gene UDP-galactose-4-epimerase Neighboring gene lysophospholipase 2 Neighboring gene PITH domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ketone body biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxymethylglutaryl-CoA lyase, mitochondrial
    Names
    3-hydroxymethyl-3-methylglutaryl-CoA lyase
    3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
    XP_014986375.1
    XP_014986390.1
    XP_028694039.1
    XP_028694053.1
    XP_028694055.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      200922420..200964472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028838220.1 → XP_028694053.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X4

      Conserved Domains (1) summary
      cd07938
      Location:45 → 282
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

    2. XM_028838206.1 → XP_028694039.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      G7MHM7
      Conserved Domains (1) summary
      cd07938
      Location:45 → 318
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

    3. XM_015130889.2 → XP_014986375.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      F7CQU2, G7MHM7, H9Z8B6
      Related
      ENSMMUP00000048063.1, ENSMMUT00000060965.2
      Conserved Domains (1) summary
      cd07938
      Location:35 → 308
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

    4. XM_015130904.2 → XP_014986390.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A5K1UZL0, G7MHM7
      Related
      ENSMMUP00000025677.4, ENSMMUT00000027454.4
      Conserved Domains (1) summary
      cd07938
      Location:10 → 283
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

    5. XM_028838222.1 → XP_028694055.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      G7MHM7
      Conserved Domains (1) summary
      cd07938
      Location:35 → 272
      DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    Nucleotide Protein
    Heading Accession and Version

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