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    PLCB2 phospholipase C beta 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701951, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLCB2provided by VGNC
    Official Full Name
    phospholipase C beta 2provided by VGNC
    Primary source
    VGNC:VGNC:76164
    See related
    Ensembl:ENSMMUG00000020535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PLCB2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (16697480..16717629, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (16611143..16631312, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene PAK6 antisense RNA 1 Neighboring gene ankyrin repeat domain 63 Neighboring gene 60S acidic ribosomal protein P0 pseudogene Neighboring gene InaF motif containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    Names
    1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
    NP_001253955.1
    XP_014997351.1
    XP_014997352.1
    XP_028706117.1
    XP_028706118.1
    XP_028706119.1
    XP_028706120.1
    XP_028706121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267026.1 → NP_001253955.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

      See identical proteins and their annotated locations for NP_001253955.1

      Status: PROVISIONAL

      Source sequence(s)
      JU470782
      UniProtKB/TrEMBL
      F7D8C0, H9YV70
      Related
      ENSMMUP00000027046.4, ENSMMUT00000028901.4
      Conserved Domains (8) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02222
      Location:219 → 800
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:979 → 1153
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1104 → 1114
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:986 → 1123
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      16697480..16717629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141866.2 → XP_014997352.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

      UniProtKB/TrEMBL
      F7D8C0, H9ZA60
      Conserved Domains (8) summary
      cd00275
      Location:677 → 798
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 645
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02222
      Location:219 → 796
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:975 → 1149
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1100 → 1110
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:982 → 1119
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_028850284.1 → XP_028706117.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5QX17, F7D8C0
      Related
      ENSMMUP00000052597.2, ENSMMUT00000072961.2
      Conserved Domains (6) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG5281
      Location:815 → 1111
      COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:964 → 1138
      PLC-beta_C; PLC-beta C terminal
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    3. XM_015141865.2 → XP_014997351.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

      UniProtKB/TrEMBL
      F7D8C0
      Conserved Domains (8) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      PLN02222
      Location:219 → 800
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:978 → 1152
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:220 → 311
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cd16269
      Location:1103 → 1113
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:985 → 1122
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. XM_028850286.1 → XP_028706119.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

      Conserved Domains (4) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    5. XM_028850287.1 → XP_028706120.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

      Conserved Domains (4) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    6. XM_028850285.1 → XP_028706118.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

      Conserved Domains (4) summary
      cd00275
      Location:681 → 802
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    7. XM_028850288.1 → XP_028706121.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6

      Conserved Domains (4) summary
      cd00275
      Location:681 → 773
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 649
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    RNA

    1. XR_003730904.1 RNA Sequence

    2. XR_003730905.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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