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    TYROBP transmembrane immune signaling adaptor TYROBP [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574207, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TYROBPprovided by VGNC
    Official Full Name
    transmembrane immune signaling adaptor TYROBPprovided by VGNC
    Primary source
    VGNC:VGNC:111180
    Locus tag
    EGK_10506
    See related
    Ensembl:ENSMMUG00000008004
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TYROBP in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (35319528..35323792, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (31826158..31830358, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor like protein 1 Neighboring gene NFKB inhibitor delta Neighboring gene hematopoietic cell signal transducer Neighboring gene leucine rich repeat and fibronectin type III domain containing 3 Neighboring gene LYR motif-containing protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microglial cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta1 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neutrophil activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macrophage fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of microglial cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TYRO protein tyrosine kinase-binding protein
    Names
    DAP12
    DNAX-activation protein 12
    TYRO protein tyrosine kinase binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032867.1 → NP_001028039.1  TYRO protein tyrosine kinase-binding protein precursor

      See identical proteins and their annotated locations for NP_001028039.1

      Status: PROVISIONAL

      Source sequence(s)
      AF321611
      UniProtKB/Swiss-Prot
      Q8WNQ8
      UniProtKB/TrEMBL
      A0A1I7Q460, A0A8J8XNR1, G7NMS6, H9EUS7
      Related
      ENSMMUP00000010492.3, ENSMMUT00000011192.4

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      35319528..35323792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015123563.2 → XP_014979049.1  TYRO protein tyrosine kinase-binding protein isoform X2

      Conserved Domains (1) summary
      pfam07213
      Location:22 → 79
      DAP10; DAP10 membrane protein

    2. XM_015123562.2 → XP_014979048.1  TYRO protein tyrosine kinase-binding protein isoform X1

      Conserved Domains (1) summary
      PTZ00449
      Location:23 → 91
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WNQ8.1 GenPept UniProtKB/Swiss-Prot:Q8WNQ8

    Gene LinkOut

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