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    DRD2 dopamine receptor D2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694181, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DRD2provided by VGNC
    Official Full Name
    dopamine receptor D2provided by VGNC
    Primary source
    VGNC:VGNC:71989
    See related
    Ensembl:ENSMMUG00000014334
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DRD2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (106549673..106616381, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (106270721..106337408, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene uncharacterized LOC106993478 Neighboring gene uncharacterized LOC114672403

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nader MA, et al. Nat Neurosci, 2006 Aug. PMID 16829955
    2. Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons. Mueller A, et al. Cereb Cortex, 2020 Jan 10. PMID 31038690, Free PMC Article
    3. Dopamine Receptors Influence Internally Generated Oscillations during Rule Processing in Primate Prefrontal Cortex. Ott T, et al. J Cogn Neurosci, 2018 May. PMID 29488849
    4. Dopamine receptors differentially enhance rule coding in primate prefrontal cortex neurons. Ott T, et al. Neuron, 2014 Dec 17. PMID 25482027
    5. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Sander CY, et al. Proc Natl Acad Sci U S A, 2013 Jul 2. PMID 23723346, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons.
      Title: Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons.
    2. Study shows that blocking dopamine D1Rs or stimulating dopamine D2Rs increased low-frequency theta and alpha oscillations known to be involved in learning and memory. In contrast, only D1R inhibition enhanced high-frequency beta oscillations, whereas only D2R stimulation increased gamma oscillations linked to top-down and bottom-up attentional processing.
      Title: Dopamine Receptors Influence Internally Generated Oscillations during Rule Processing in Primate Prefrontal Cortex.
    3. findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.
      Title: Dopamine receptors differentially enhance rule coding in primate prefrontal cortex neurons.
    4. Extrastriatal D2, D3, and D4 receptor activation in external pallidal segments also influences direct pathway elements in the basal ganglia under normal and parkinsonian conditions.
      Title: Extrastriatal D2-like receptors modulate basal ganglia pathways in normal and Parkinsonian monkeys.
    5. Mapped associations occur between changes in D2 and D3 dopamine receptor occupancy and brain hemodynamics
      Title: Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI.
    6. These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.
      Title: PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D(2) dopamine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      106549673..106616381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001085571.4 → XP_001085571.1  D(2) dopamine receptor

      See identical proteins and their annotated locations for XP_001085571.1

      UniProtKB/TrEMBL
      F7CYH8, G7NC25
      Related
      ENSMMUP00000018834.2, ENSMMUT00000020122.4
      Conserved Domains (1) summary
      cd15309
      Location:35 → 437
      7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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