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    CBLB Cbl proto-oncogene B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703879, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CBLBprovided by VGNC
    Official Full Name
    Cbl proto-oncogene Bprovided by VGNC
    Primary source
    VGNC:VGNC:70555
    See related
    Ensembl:ENSMMUG00000007565
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CBLB in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (170326179..170540266)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (26616800..26830260, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676445 Neighboring gene uncharacterized LOC106996755 Neighboring gene uncharacterized LOC114676446 Neighboring gene U6 spliceosomal RNA Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC114676187

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    e3 ubiquitin-protein ligase CBL-B-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      170326179..170540266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015129773.2 → XP_014985259.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      A0A5F8ACF3, G7MK35
      Related
      ENSMMUP00000071708.1, ENSMMUT00000100980.1
      Conserved Domains (5) summary
      cd09920
      Location:248 → 344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373 → 415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931 → 971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44 → 167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171 → 254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    2. XM_015129772.2 → XP_014985258.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      A0A5F8ACF3, G7MK35
      Conserved Domains (5) summary
      cd09920
      Location:248 → 344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373 → 415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931 → 971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44 → 167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171 → 254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    3. XM_015129775.2 → XP_014985261.1  E3 ubiquitin-protein ligase CBL-B isoform X2

      UniProtKB/TrEMBL
      F6T053, G7MK35
      Related
      ENSMMUP00000009923.3, ENSMMUT00000010578.4
      Conserved Domains (5) summary
      cd09920
      Location:248 → 344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:887 → 927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354 → 419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44 → 164
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171 → 254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    4. XM_015129774.2 → XP_014985260.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      A0A5F8ACF3, G7MK35
      Related
      ENSMMUP00000080034.1, ENSMMUT00000099950.1
      Conserved Domains (5) summary
      cd09920
      Location:248 → 344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373 → 415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931 → 971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44 → 167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171 → 254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    5. XM_015129776.2 → XP_014985262.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      UniProtKB/TrEMBL
      G7MK35
      Conserved Domains (5) summary
      cd09920
      Location:96 → 192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:221 → 263
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:779 → 819
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:1 → 15
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:19 → 102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    6. XM_028844661.1 → XP_028700494.1  E3 ubiquitin-protein ligase CBL-B isoform X4

      Conserved Domains (3) summary
      cd09920
      Location:1 → 84
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:671 → 711
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:94 → 159
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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