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    HNF1B HNF1 homeobox B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714540, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HNF1Bprovided by VGNC
    Official Full Name
    HNF1 homeobox Bprovided by VGNC
    Primary source
    VGNC:VGNC:73384
    Locus tag
    EGK_08628
    See related
    Ensembl:ENSMMUG00000003431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HNF1B in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (33352867..33414734)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (43712211..43775208, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114673102 Neighboring gene TBC1 domain family member 3B-like Neighboring gene uncharacterized LOC114673106 Neighboring gene uncharacterized LOC114673108 Neighboring gene uncharacterized LOC106994026 Neighboring gene DExD-box helicase 52 Neighboring gene microRNA mir-378j

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 1-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001194548.3 → NP_001181477.1  hepatocyte nuclear factor 1-beta

      See identical proteins and their annotated locations for NP_001181477.1

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02000162
      UniProtKB/TrEMBL
      A0A8J8Y4G0, F7F9C9, G7NI16
      Related
      ENSMMUP00000004573.2, ENSMMUT00000004853.4
      Conserved Domains (3) summary
      cd00086
      Location:232 → 305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:314 → 550
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 173
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      33352867..33414734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028835662.1 → XP_028691495.1  hepatocyte nuclear factor 1-beta isoform X2

      Conserved Domains (3) summary
      cd00086
      Location:206 → 279
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:288 → 426
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
      pfam04814
      Location:8 → 174
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    2. XM_001112182.4 → XP_001112182.2  hepatocyte nuclear factor 1-beta isoform X1

      See identical proteins and their annotated locations for XP_001112182.2

      Conserved Domains (3) summary
      cd00086
      Location:206 → 279
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:288 → 524
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 173
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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