frc fringe connection [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: frcprovided by FlyBase
Official Full Name: fringe connectionprovided by FlyBase
Primary source: FLYBASE:FBgn0042641
Locus tag: Dmel_CG3874
See related: AllianceGenome:FB:FBgn0042641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.5; anon-WO0172774.7; CG3874; dFRC; Dmel\CG3874; Frc; FRC; l(3)00073; l(3)02619; l(3)10098; l(3)j2E3; l(3)L6750; l(3)S070006; UDP-GlcNAc/UDP-GlcUA; ust74C; UST74C
Summary: Enables antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; pyrimidine nucleotide-sugar transmembrane transport; and regionalization. Located in Golgi medial cisterna. Is expressed in adult fat body; adult head; and organism. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Orthologous to several human genes including SLC35D1 (solute carrier family 35 member D1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17428936..17433190, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17422036..17426290, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables GDP-fucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables GDP-mannose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-N-acetylgalactosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables UDP-galactose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-galactose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables UDP-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucuronic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucuronic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-xylose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-galactose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-glucuronic acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-xylose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-sugar transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed

Names: CG3874-PA; CG3874-PB; Fringe-connection; UDP-sugar transporter in 74C; frc-PA; frc-PB

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