Ilp8 Insulin-like peptide 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ilp8provided by FlyBase
Official Full Name: Insulin-like peptide 8provided by FlyBase
Primary source: FLYBASE:FBgn0036690
Locus tag: Dmel_CG14059
See related: AllianceGenome:FB:FBgn0036690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14059; DILP 8; dILP-8; DILP1 8; dilp8; dILP8; Dilp8; DILP8; DILPs; dlip8; dlp; Dmel\CG14059; ilp8; ILP8; ILPs; Lgr3
Summary: Enables G protein-coupled receptor binding activity and receptor ligand activity. Involved in several processes, including cellular response to gamma radiation; negative regulation of pupariation; and positive regulation of cAMP-mediated signaling. Located in extracellular space. Is expressed in several structures, including embryonic/larval fat body; follicle cell; imaginal disc; larval brain; and peripodial epithelium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 73E4-73E4; 3-45 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17029812..17032080, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17022912..17025180, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc.
Title: Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc.
Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay.
Title: Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay.
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
Title: The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants.
Title: Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants.
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.
Title: Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.
Early pupal stage is a novel Dilp8 mediated post-pupariation checkpoint; this provides further evidence for interorgan signaling during development, wherein a peripheral tissue influences the CNS driven endocrine function.
Title: Activated Ras/JNK driven Dilp8 in imaginal discs adversely affects organismal homeostasis during early pupal stage in Drosophila, a new checkpoint for development.
demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development
Title: Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila.
Activation of Dmp53 in the growth-depleted territory induces the expression of the Eiger, which activates the JNK stress signaling pathway. JNK-dependent expression of the systemic hormone dILP8 reduces the growth and final size of adjacent territories, the production of Reactive Oxygen Species downstream of JNK and the apoptotic machinery act locally to regulate the proliferation of adjacent epithelial cells.
Title: Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila.
These results indicate that growth coordination of organs is connected to their growth status through a feedback loop involving Hpo and Dilp8 signalling pathways.
Title: The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.
Here we demonstrate that the Drosophila relaxin receptor homolog Lgr3, a leucine-rich repeat-containing G-protein-coupled receptor, is required for Dilp8-dependent growth coordination and developmental delay during the regeneration checkpoint; we demonstrate that Lgr3 activity in both the CNS and PG is necessary for NOS activation in the PG following damage
Title: Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in chorion-containing eggshell formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in determination of bilateral symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in egg chorion	IC Inferred by Curator more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info