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    BDNF brain derived neurotrophic factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701245, updated on 7-Dec-2024

    Summary

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    Official Symbol
    BDNFprovided by VGNC
    Official Full Name
    brain derived neurotrophic factorprovided by VGNC
    Primary source
    VGNC:VGNC:99552
    Locus tag
    EGK_06399
    See related
    Ensembl:ENSMMUG00000008634
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See BDNF in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (37727375..37797626)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (38238851..38309109)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 18A Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene uncharacterized LOC114672299 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques. Cirulli F, et al. Psychoneuroendocrinology, 2011 Apr. PMID 21145664, Free PMC Article
    2. Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys. Mori T, et al. Exp Brain Res, 2006 May. PMID 16307254
    3. Molecular correlates of spontaneous activity in non-human primates. Mitchell AC, et al. J Neural Transm (Vienna), 2010 Dec. PMID 20838826, Free PMC Article
    4. Comparison of mammalian, chicken and Xenopus brain-derived neurotrophic factor coding sequences. Isackson PJ, et al. FEBS Lett, 1991 Jul 22. PMID 1906813
    5. Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex. Purves-Tyson TD, et al. Schizophr Res, 2015 Nov. PMID 26088421

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
      Title: Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex.
    2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.
      Title: Molecular correlates of spontaneous activity in non-human primates.
    3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
      Title: A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques.
    4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
      Title: Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nerve growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurotrophic factor BDNF precursor form; brain-derived neurotrophic factor
    Names
    proBDNF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      37727375..37797626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015114599.2 → XP_014970085.1  brain-derived neurotrophic factor isoform X2

      UniProtKB/TrEMBL
      I2CTP4
      Conserved Domains (1) summary
      smart00140
      Location:141 → 248
      NGF; Nerve growth factor (NGF or beta-NGF)

    2. XM_015114601.2 → XP_014970087.1  brain-derived neurotrophic factor isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q8B8, A0A1D5R4M8, A0A8J8YBY4, F7F914, H9F8C5
      Related
      ENSMMUP00000055264.2, ENSMMUT00000078167.2
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    3. XM_015114600.2 → XP_014970086.1  brain-derived neurotrophic factor isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q8B8, A0A1D5R4M8, A0A8J8YBY4, F7F914, H9F8C5
      Related
      ENSMMUP00000044286.2, ENSMMUT00000061569.2
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    4. XM_015114602.2 → XP_014970088.1  brain-derived neurotrophic factor isoform X4

      Conserved Domains (1) summary
      smart00140
      Location:162 → 269
      NGF; Nerve growth factor (NGF or beta-NGF)

    5. XM_015114598.2 → XP_014970084.1  brain-derived neurotrophic factor isoform X1

      UniProtKB/TrEMBL
      A0A1D5QAT2
      Related
      ENSMMUP00000045150.1, ENSMMUT00000056857.2
      Conserved Domains (1) summary
      smart00140
      Location:190 → 297
      NGF; Nerve growth factor (NGF or beta-NGF)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06225.1 GenPept UniProtKB/Swiss-Prot:Q06225

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials