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    CCM2 CCM2 scaffold protein [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705037, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CCM2provided by VGNC
    Official Full Name
    CCM2 scaffold proteinprovided by VGNC
    Primary source
    VGNC:VGNC:70835
    See related
    Ensembl:ENSMMUG00000001799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CCM2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (70148106..70223260, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (63710341..63785143, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II subunit RPB1-like Neighboring gene DNA-directed RNA polymerase II subunit RPB1-like Neighboring gene NAC alpha domain containing Neighboring gene uncharacterized LOC106997433 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene myosin IG

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cerebral cavernous malformations 2 protein
    Names
    CCM2 scaffolding protein
    malcavernin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257533.1 → NP_001244462.1  cerebral cavernous malformations 2 protein

      See identical proteins and their annotated locations for NP_001244462.1

      Status: PROVISIONAL

      Source sequence(s)
      JU336614
      UniProtKB/TrEMBL
      F7GGE7, G7MLC8, H9G0F8
      Conserved Domains (2) summary
      cd13166
      Location:65 → 259
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:309 → 399
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      70148106..70223260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028844915.1 → XP_028700748.1  cerebral cavernous malformations 2 protein isoform X3

      UniProtKB/TrEMBL
      A0A5F8AGA5
      Conserved Domains (2) summary
      cd13166
      Location:65 → 231
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:322 → 412
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    2. XM_015133542.2 → XP_014989028.1  cerebral cavernous malformations 2 protein isoform X9

      UniProtKB/TrEMBL
      A0A1D5Q714, A0A1D5QWC2
      Related
      ENSMMUP00000043830.2, ENSMMUT00000054495.2
      Conserved Domains (2) summary
      cd13166
      Location:10 → 179
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:270 → 360
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    3. XM_028844918.1 → XP_028700751.1  cerebral cavernous malformations 2 protein isoform X6

      UniProtKB/TrEMBL
      A0A5F8AGA5
      Conserved Domains (2) summary
      cd13166
      Location:30 → 201
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:292 → 382
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    4. XM_028844922.1 → XP_028700755.1  cerebral cavernous malformations 2 protein isoform X13

      UniProtKB/TrEMBL
      G7MLC8
      Conserved Domains (2) summary
      pfam16545
      Location:218 → 308
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology
      cl17171
      Location:65 → 214
      PH-like; Pleckstrin homology-like domain

    5. XM_028844914.1 → XP_028700747.1  cerebral cavernous malformations 2 protein isoform X1

      UniProtKB/TrEMBL
      A0A5F8AGA5
      Conserved Domains (2) summary
      cd13166
      Location:65 → 259
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:350 → 440
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    6. XM_028844916.1 → XP_028700749.1  cerebral cavernous malformations 2 protein isoform X4

      UniProtKB/TrEMBL
      F7GGE7, G7MLC8, H9G0F8
      Related
      ENSMMUP00000002392.3, ENSMMUT00000002529.4
      Conserved Domains (2) summary
      cd13166
      Location:65 → 259
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:309 → 399
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    7. XM_028844917.1 → XP_028700750.1  cerebral cavernous malformations 2 protein isoform X5

      UniProtKB/TrEMBL
      A0A1D5Q4X9, A0A5F8AGA5
      Related
      ENSMMUP00000043093.2, ENSMMUT00000061622.2
      Conserved Domains (2) summary
      cd13166
      Location:43 → 209
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:300 → 390
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    8. XM_015133538.2 → XP_014989024.1  cerebral cavernous malformations 2 protein isoform X2

      UniProtKB/TrEMBL
      A0A1D5QD55, A0A5F8AGA5
      Related
      ENSMMUP00000045974.2, ENSMMUT00000066445.2
      Conserved Domains (2) summary
      cd13166
      Location:43 → 237
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:328 → 418
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    9. XM_028844919.1 → XP_028700752.1  cerebral cavernous malformations 2 protein isoform X8

      UniProtKB/TrEMBL
      G7MLC8
      Conserved Domains (2) summary
      cd13166
      Location:65 → 231
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:281 → 371
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    10. XM_015133545.2 → XP_014989031.1  cerebral cavernous malformations 2 protein isoform X12

      UniProtKB/TrEMBL
      A0A1D5QWC2, H9G0F6
      Related
      ENSMMUP00000052352.1, ENSMMUT00000063049.2
      Conserved Domains (2) summary
      cd13166
      Location:10 → 179
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:229 → 319
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    11. XM_015133547.2 → XP_014989033.1  cerebral cavernous malformations 2 protein isoform X14

      UniProtKB/TrEMBL
      A0A1D5QD55
      Conserved Domains (2) summary
      pfam16545
      Location:196 → 286
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology
      cl17171
      Location:43 → 192
      PH-like; Pleckstrin homology-like domain

    12. XM_028844921.1 → XP_028700754.1  cerebral cavernous malformations 2 protein isoform X11

      UniProtKB/TrEMBL
      A0A1D5QWC2, A0A5F7ZZJ1
      Related
      ENSMMUP00000071052.1, ENSMMUT00000084591.1
      Conserved Domains (2) summary
      cd13166
      Location:30 → 201
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:251 → 341
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    13. XM_028844920.1 → XP_028700753.1  cerebral cavernous malformations 2 protein isoform X10

      UniProtKB/TrEMBL
      G7MLC8
      Conserved Domains (2) summary
      cd13166
      Location:43 → 209
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:259 → 349
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology

    14. XM_015133541.2 → XP_014989027.1  cerebral cavernous malformations 2 protein isoform X7

      UniProtKB/TrEMBL
      G7MLC8, H9G0F7
      Related
      ENSMMUP00000044867.2, ENSMMUT00000053228.2
      Conserved Domains (2) summary
      cd13166
      Location:43 → 237
      PTB_CCM2; Cerebral cavernous malformation 2 FERM domain C-lobe
      pfam16545
      Location:287 → 377
      CCM2_C; Cerebral cavernous malformation protein, harmonin-homology
    Nucleotide Protein
    Heading Accession and Version

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