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    SMG5 SMG5 nonsense mediated mRNA decay factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719446, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SMG5provided by VGNC
    Official Full Name
    SMG5 nonsense mediated mRNA decay factorprovided by VGNC
    Primary source
    VGNC:VGNC:77768
    Locus tag
    EGK_01414
    See related
    Ensembl:ENSMMUG00000000090
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SMG5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (94684481..94720231)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (130861158..130897680, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene glycosylated lysosomal membrane protein Neighboring gene transmembrane protein 79 Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene bone gamma-carboxyglutamate protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of telomerase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nonsense-mediated mRNA decay factor SMG5; protein SMG5
    Names
    smg-5 homolog, nonsense mediated mRNA decay factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260844.1 → NP_001247773.1  nonsense-mediated mRNA decay factor SMG5

      See identical proteins and their annotated locations for NP_001247773.1

      Status: PROVISIONAL

      Source sequence(s)
      JV046579
      UniProtKB/TrEMBL
      A0A5F8ADX1, A0A8J8XIH2, F6W9F4, G7MDZ3
      Related
      ENSMMUP00000075161.1, ENSMMUT00000097236.1
      Conserved Domains (4) summary
      cd09884
      Location:855 → 1013
      PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
      sd00006
      Location:172 → 206
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:197 → 412
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:77 → 187
      EST1; Telomerase activating protein Est1

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      94684481..94720231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015110242.2 → XP_014965728.1  protein SMG5 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZNY9
      Conserved Domains (4) summary
      cd09884
      Location:692 → 850
      PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
      sd00006
      Location:9 → 43
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:34 → 249
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:2 → 24
      EST1; Telomerase activating protein Est1
    Nucleotide Protein
    Heading Accession and Version

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