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    Sec24AB Secretory 24AB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec24ABprovided by FlyBase
    Official Full Name
    Secretory 24ABprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033460
    Locus tag
    Dmel_CG1472
    See related
    AllianceGenome:FB:FBgn0033460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1472; Dmel\CG1472; Hau; sec24; Sec24; SEC24
    Summary
    Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in adult head. Orthologous to several human genes including SEC24A (SEC24 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec24AB in Genome Data Viewer
    Location:
    46C1-46C2; 2-61 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9876232..9882357, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5763737..5769862, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45138 Neighboring gene pendolino Neighboring gene Linking immunity and metabolism Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45467 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila. Iyer SC, et al. J Cell Sci, 2013 Oct 15. PMID 23902691, Free PMC Article
    2. Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis. Matsuura Y, et al. Int J Mol Sci, 2024 Apr 20. PMID 38674111, Free PMC Article
    3. Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation. Norum M, et al. PLoS One, 2010 May 24. PMID 20520821, Free PMC Article
    4. Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in Drosophila. Förster D, et al. Curr Biol, 2010 Jan 12. PMID 20045324
    5. A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation. Zacharogianni M, et al. Elife, 2014 Nov 11. PMID 25386913, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    secretory 24AB
    Names
    CG1472-PA
    CG1472-PB
    CG1472-PC
    Sec24AB ortholog
    Sec24AB-PA
    Sec24AB-PB
    Sec24AB-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9876232..9882357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299329.1 → NP_001286258.1  secretory 24AB, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEK8
      Conserved Domains (6) summary
      COG5028
      Location:361 → 1162
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:560 → 801
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:487 → 523
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:901 → 998
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:802 → 886
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      cl15697
      Location:1042 → 1089
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. NM_136687.5 → NP_610531.1  secretory 24AB, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z813
      Related
      FBpp0087536
      Conserved Domains (6) summary
      COG5028
      Location:383 → 1184
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:582 → 823
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:509 → 545
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:923 → 1020
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:824 → 908
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      cl15697
      Location:1064 → 1111
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    3. NM_001299328.1 → NP_001286257.1  secretory 24AB, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z813
      Conserved Domains (6) summary
      COG5028
      Location:383 → 1184
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:582 → 823
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:509 → 545
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:923 → 1020
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:824 → 908
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      cl15697
      Location:1064 → 1111
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEK8 A0A0B4LEK8
    A1Z813 A1Z813
    Q95R66 Q95R66

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