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    Tab2 TAK1-associated binding protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37216, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tab2provided by FlyBase
    Official Full Name
    TAK1-associated binding protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0086358
    Locus tag
    Dmel_CG7417
    See related
    AllianceGenome:FB:FBgn0086358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7417; cg7417; CG7417; Dmel\CG7417; dTab2; dTAB2; galere; ORF1; TAB; tab-2; tab2; TAB2
    Summary
    Enables signaling adaptor activity. Involved in regulation of defense response and tumor necrosis factor-mediated signaling pathway. Is expressed in several structures, including Kenyon cell; ganglia; mushroom body; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to several human genes including TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tab2 in Genome Data Viewer
    Location:
    56C8-56C9; 2-88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19292529..19304508)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15180034..15192013)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene FK506-binding protein 12kD Neighboring gene Myb-interacting protein 40 Neighboring gene Acyl-CoA dehydrogenase very long chain Neighboring gene Endophilin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subdivision of the Drosophila mushroom bodies by enhancer-trap expression patterns. Yang MY, et al. Neuron, 1995 Jul. PMID 7619529
    2. Metamorphosis of the mushroom bodies; large-scale rearrangements of the neural substrates for associative learning and memory in Drosophila. Armstrong JD, et al. Learn Mem, 1998 May-Jun. PMID 10454375, Free PMC Article
    3. The mushroom bodies of Drosophila melanogaster: an immunocytological and golgi study of Kenyon cell organization in the calyces and lobes. Strausfeld NJ, et al. Microsc Res Tech, 2003 Oct 1. PMID 12966500
    4. The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling. Kodra AL, et al. Genetics, 2024 Sep 4. PMID 38985651, Free PMC Article
    5. Visual input regulates circuit configuration in courtship conditioning of Drosophila melanogaster. Joiner MA, et al. Learn Mem, 2000 Jan. PMID 10706600, Free PMC Article

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAB2 is a functionally conserved component of the tumor necrosis factor/Eiger signaling pathway.
      Title: A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component.
    2. dTAB2 is specifically required for PGN-induced activation of JNK and NF-kappaB signaling pathways.
      Title: Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB.
    3. Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Imd pathway, which controls antimicrobial peptide expression in Drosophila.
      Title: Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidoglycan recognition protein signaling pathway HMP PubMed 
    involved_in peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria HMP PubMed 
    involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TAK1-associated binding protein 2
    Names
    CG7417-PA
    CG7417-PB
    CG7417-PC
    TAK1-associated binding Protein2
    TGF-beta-activated kinase 1/MAP3K7 binding protein 2
    Tab2-PA
    Tab2-PB
    Tab2-PC
    galere

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19292529..19304508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274157.1 → NP_001261086.1  TAK1-associated binding protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG87, Q4TZQ4
      Conserved Domains (4) summary
      smart00547
      Location:765 → 789
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:98 → 138
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:767 → 786
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam14772
      Location:528 → 602
      NYD-SP28; Sperm tail

    2. NM_137564.3 → NP_611408.2  TAK1-associated binding protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611408.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4TZQ4, Q6NQZ7
      Related
      FBpp0085704
      Conserved Domains (4) summary
      smart00547
      Location:765 → 789
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:98 → 138
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:767 → 786
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam14772
      Location:528 → 602
      NYD-SP28; Sperm tail

    3. NM_001259488.2 → NP_001246417.1  TAK1-associated binding protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4TZQ4, Q6NQZ7
      Conserved Domains (4) summary
      smart00547
      Location:765 → 789
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:98 → 138
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:767 → 786
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam14772
      Location:528 → 602
      NYD-SP28; Sperm tail
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG87 A0A0B4KG87
    Q4TZQ4 Q4TZQ4
    Q6NQZ7 Q6NQZ7
    Q9NFL3 Q9NFL3

    Gene LinkOut

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