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    KALRN kalirin RhoGEF kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 715567, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KALRNprovided by VGNC
    Official Full Name
    kalirin RhoGEF kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:84161
    See related
    Ensembl:ENSMMUG00000003851
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See KALRN in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (151580354..152273292, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (45272761..45964642)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene integrin subunit beta 5 Neighboring gene uncharacterized LOC114676414 Neighboring gene uridine monophosphate synthetase Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106996799 Neighboring gene uncharacterized LOC114676415 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene uncharacterized LOC114676416 Neighboring gene rhophilin associated tail protein 1 Neighboring gene coiled-coil domain containing 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kalirin
    XP_014985513.1
    XP_014985514.1
    XP_014985515.1
    XP_014985516.1
    XP_014985518.1
    XP_014985519.1
    XP_014985520.1
    XP_014985521.1
    XP_014985522.1
    XP_014985523.1
    XP_014985524.1
    XP_014985525.1
    XP_014985527.1
    XP_014985529.1
    XP_014985530.1
    XP_028700388.1
    XP_028700389.1
    XP_028700390.1
    XP_028700391.1
    XP_028700392.1
    XP_028700393.1
    XP_028700396.1
    XP_028700397.1
    XP_028700398.1
    XP_028700399.1
    XP_028700400.1
    XP_028700401.1
    XP_028700402.1
    XP_028700403.1
    XP_028700404.1
    XP_028700405.1
    XP_028700406.1
    XP_028700407.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      151580354..152273292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015130036.2 → XP_014985522.1  kalirin isoform X10

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2468 → 2542
      Ig; Immunoglobulin domain
      cd11852
      Location:1629 → 1688
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2305 → 2363
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2664 → 2918
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2549 → 2640
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1264 → 1434
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 755
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2451 → 2545
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1441 → 1563
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2087 → 2221
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2670 → 2917
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1474 → 1559
      PH; PH domain
      pfam00621
      Location:1913 → 2083
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1686 → 1912
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1111 → 1280
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    2. XM_015130035.2 → XP_014985521.1  kalirin isoform X8

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2477 → 2551
      Ig; Immunoglobulin domain
      cd11852
      Location:1638 → 1697
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2314 → 2372
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2673 → 2927
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2558 → 2649
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1273 → 1443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 755
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2460 → 2554
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1450 → 1572
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2096 → 2230
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2679 → 2926
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1483 → 1568
      PH; PH domain
      pfam00621
      Location:1922 → 2092
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1695 → 1921
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1088 → 1227
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    3. XM_015130038.2 → XP_014985524.1  kalirin isoform X12

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2457 → 2531
      Ig; Immunoglobulin domain
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2294 → 2352
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2653 → 2907
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2538 → 2629
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2440 → 2534
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2076 → 2210
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2659 → 2906
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1496 → 1581
      PH; PH domain
      pfam00621
      Location:1902 → 2072
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1846
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1101 → 1240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    4. XM_015130029.2 → XP_014985515.1  kalirin isoform X3

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2489 → 2563
      Ig; Immunoglobulin domain
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2326 → 2384
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2685 → 2939
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2570 → 2661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2472 → 2566
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2108 → 2242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2691 → 2938
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1496 → 1581
      PH; PH domain
      pfam00621
      Location:1934 → 2104
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1933
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1101 → 1240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    5. XM_015130037.2 → XP_014985523.1  kalirin isoform X11

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2458 → 2532
      Ig; Immunoglobulin domain
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2295 → 2353
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2654 → 2908
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2539 → 2630
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2441 → 2535
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2077 → 2211
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2660 → 2907
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1496 → 1581
      PH; PH domain
      pfam00621
      Location:1903 → 2073
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1847
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1101 → 1240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    6. XM_015130027.2 → XP_014985513.1  kalirin isoform X1

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2490 → 2564
      Ig; Immunoglobulin domain
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2327 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2686 → 2940
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2571 → 2662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2473 → 2567
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2109 → 2243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2692 → 2939
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1496 → 1581
      PH; PH domain
      pfam00621
      Location:1935 → 2105
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1934
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1101 → 1240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    7. XM_028844555.1 → XP_028700388.1  kalirin isoform X9

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (13) summary
      smart00150
      Location:1137 → 1237
      SPEC; Spectrin repeats
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2327 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2551 → 2642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2109 → 2243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2672 → 2919
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1935 → 2104
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      pfam07679
      Location:2453 → 2547
      I-set; Immunoglobulin I-set domain

    8. XM_015130028.2 → XP_014985514.1  kalirin isoform X2

      UniProtKB/TrEMBL
      F6VU49, G7MKL1
      Related
      ENSMMUP00000021925.4, ENSMMUT00000023431.4
      Conserved Domains (13) summary
      smart00150
      Location:1137 → 1237
      SPEC; Spectrin repeats
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2326 → 2384
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2570 → 2661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2109 → 2243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2691 → 2938
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1935 → 2104
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2472 → 2566
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1708 → 1925
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    9. XM_015130044.2 → XP_014985530.1  kalirin isoform X27

      Conserved Domains (9) summary
      cd00096
      Location:791 → 865
      Ig; Immunoglobulin domain
      cd11853
      Location:628 → 686
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:987 → 1241
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:872 → 963
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:774 → 868
      I-set; Immunoglobulin I-set domain
      cd13241
      Location:410 → 544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:993 → 1240
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:236 → 406
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    10. XM_015130033.2 → XP_014985519.1  kalirin isoform X6

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2481 → 2555
      Ig; Immunoglobulin domain
      cd11852
      Location:1642 → 1701
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2318 → 2376
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2677 → 2931
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2562 → 2653
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1277 → 1447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:893 → 1122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2464 → 2558
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1454 → 1576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2100 → 2234
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2683 → 2930
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1487 → 1572
      PH; PH domain
      pfam00621
      Location:1926 → 2096
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1699 → 1925
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1124 → 1293
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    11. XM_015130030.2 → XP_014985516.1  kalirin isoform X4

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2488 → 2562
      Ig; Immunoglobulin domain
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2325 → 2383
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2684 → 2938
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2569 → 2660
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2471 → 2565
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2690 → 2937
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1494 → 1579
      PH; PH domain
      pfam00621
      Location:1933 → 2103
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1706 → 1932
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1099 → 1238
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    12. XM_015130034.2 → XP_014985520.1  kalirin isoform X7

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (16) summary
      cd00096
      Location:2479 → 2553
      Ig; Immunoglobulin domain
      cd11852
      Location:1640 → 1699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2316 → 2374
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:2675 → 2929
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2560 → 2651
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2462 → 2556
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2098 → 2232
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2681 → 2928
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00169
      Location:1485 → 1570
      PH; PH domain
      pfam00621
      Location:1924 → 2094
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1697 → 1923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1122 → 1291
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    13. XM_015130032.2 → XP_014985518.1  kalirin isoform X5

      UniProtKB/TrEMBL
      A0A1D5QWV4, G7MKL1
      Related
      ENSMMUP00000052534.2, ENSMMUT00000075381.2
      Conserved Domains (13) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2324 → 2382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2568 → 2659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2689 → 2936
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1933 → 2102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2470 → 2564
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    14. XM_028844569.1 → XP_028700402.1  kalirin isoform X28

      UniProtKB/TrEMBL
      F6VU54
      Related
      ENSMMUP00000021924.4, ENSMMUT00000023430.4
      Conserved Domains (8) summary
      cd11853
      Location:627 → 685
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:871 → 962
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:410 → 544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:992 → 1239
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:236 → 405
      RhoGEF; RhoGEF domain
      pfam07679
      Location:773 → 867
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:25 → 235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:765 → 768
      Ig; Ig strand A [structural motif]

    15. XM_015130039.2 → XP_014985525.1  kalirin isoform X13

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (14) summary
      cd00096
      Location:2490 → 2564
      Ig; Immunoglobulin domain
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2327 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2571 → 2662
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:2473 → 2567
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2109 → 2243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:1496 → 1581
      PH; PH domain
      pfam00621
      Location:1935 → 2105
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1934
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1101 → 1240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    16. XM_028844556.1 → XP_028700389.1  kalirin isoform X14

      Conserved Domains (11) summary
      smart00150
      Location:1137 → 1237
      SPEC; Spectrin repeats
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2327 → 2385
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2109 → 2243
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1935 → 2104
      RhoGEF; RhoGEF domain
      pfam12297
      Location:793 → 945
      EVC2_like; Ellis van Creveld protein 2 like protein
      pfam16609
      Location:1708 → 1892
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    17. XM_028844559.1 → XP_028700392.1  kalirin isoform X18

      Conserved Domains (10) summary
      smart00150
      Location:1128 → 1228
      SPEC; Spectrin repeats
      cd11852
      Location:1642 → 1701
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2284 → 2342
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1277 → 1447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:893 → 1122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1454 → 1576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2067 → 2201
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1893 → 2062
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1699 → 1837
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    18. XM_028844557.1 → XP_028700390.1  kalirin isoform X15

      Conserved Domains (10) summary
      smart00150
      Location:1137 → 1237
      SPEC; Spectrin repeats
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2325 → 2383
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2108 → 2242
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1934 → 2103
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1924
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    19. XM_015130041.2 → XP_014985527.1  kalirin isoform X17

      Conserved Domains (11) summary
      cd11852
      Location:1651 → 1710
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2294 → 2352
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2077 → 2211
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:1496 → 1581
      PH; PH domain
      pfam00621
      Location:1903 → 2073
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1708 → 1847
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl02488
      Location:1101 → 1240
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    20. XM_028844558.1 → XP_028700391.1  kalirin isoform X16

      UniProtKB/TrEMBL
      G7MKL1
      Conserved Domains (10) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2323 → 2381
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2106 → 2240
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1932 → 2101
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1706 → 1931
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    21. XM_028844574.1 → XP_028700407.1  kalirin isoform X33

      Conserved Domains (4) summary
      cd11853
      Location:594 → 652
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:377 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 147
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    22. XM_028844573.1 → XP_028700406.1  kalirin isoform X32

      Conserved Domains (4) summary
      cd11853
      Location:595 → 653
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:377 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 147
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    23. XM_028844570.1 → XP_028700403.1  kalirin isoform X29

      Conserved Domains (4) summary
      cd11853
      Location:626 → 684
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:409 → 543
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:235 → 404
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 234
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    24. XM_028844572.1 → XP_028700405.1  kalirin isoform X31

      Conserved Domains (4) summary
      cd11853
      Location:595 → 653
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:378 → 512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 148
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    25. XM_028844571.1 → XP_028700404.1  kalirin isoform X30

      Conserved Domains (4) summary
      cd11853
      Location:596 → 654
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:378 → 512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 148
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    26. XM_028844560.1 → XP_028700393.1  kalirin isoform X19

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1137 → 1237
      SPEC; Spectrin repeats
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1286 → 1456
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 768
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1463 → 1585
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    27. XM_028844568.1 → XP_028700401.1  kalirin isoform X26

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1113 → 1213
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1262 → 1432
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 753
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1439 → 1561
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    28. XM_028844566.1 → XP_028700399.1  kalirin isoform X24

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1122 → 1222
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1271 → 1441
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 753
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1448 → 1570
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    29. XM_028844564.1 → XP_028700397.1  kalirin isoform X22

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1126 → 1226
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    30. XM_015130043.2 → XP_014985529.1  kalirin isoform X20

      UniProtKB/TrEMBL
      A0A1D5RDL8, F7HAC1, H9G1H6
      Related
      ENSMMUP00000005133.4, ENSMMUT00000005453.4
      Conserved Domains (5) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    31. XM_028844567.1 → XP_028700400.1  kalirin isoform X25

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1115 → 1215
      SPEC; Spectrin repeats
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1264 → 1434
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 755
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1441 → 1563
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    32. XM_028844565.1 → XP_028700398.1  kalirin isoform X23

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1124 → 1224
      SPEC; Spectrin repeats
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1273 → 1443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:539 → 755
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1450 → 1572
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    33. XM_028844563.1 → XP_028700396.1  kalirin isoform X21

      UniProtKB/TrEMBL
      A0A1D5RDL8
      Conserved Domains (5) summary
      smart00150
      Location:1128 → 1228
      SPEC; Spectrin repeats
      smart00516
      Location:41 → 179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1277 → 1447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:893 → 1122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1454 → 1576
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    Nucleotide Protein
    Heading Accession and Version

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