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    NOS1 nitric oxide synthase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693781, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NOS1provided by VGNC
    Official Full Name
    nitric oxide synthase 1provided by VGNC
    Primary source
    VGNC:VGNC:75368
    See related
    Ensembl:ENSMMUG00000014027
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NOS1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (116946412..117098744, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (117289857..117435491, complement)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107001038 Neighboring gene F-box protein 21 Neighboring gene uncharacterized LOC114670967 Neighboring gene uncharacterized LOC114670968 Neighboring gene kinase suppressor of ras 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nitric oxide synthase, brain
    Names
    nitric oxide synthase 1 (neuronal)
    XP_028685784.1
    XP_028685785.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      116946412..117098744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028829951.1 → XP_028685784.1  nitric oxide synthase, brain

      UniProtKB/TrEMBL
      F7AVJ6, F7AVK5
      Related
      ENSMMUP00000018436.4, ENSMMUT00000019691.4
      Conserved Domains (5) summary
      cd06202
      Location:1001 → 1404
      Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
      cd00795
      Location:305 → 716
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      cd00992
      Location:15 → 98
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:41 → 197
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      pfam00258
      Location:762 → 935
      Flavodoxin_1

    2. XM_028829952.1 → XP_028685785.1  nitric oxide synthase, brain

      UniProtKB/TrEMBL
      F7AVJ6, F7AVK5
      Related
      ENSMMUP00000068918.1, ENSMMUT00000081726.1
      Conserved Domains (5) summary
      cd06202
      Location:1001 → 1404
      Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
      cd00795
      Location:305 → 716
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      cd00992
      Location:15 → 98
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:41 → 197
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      pfam00258
      Location:762 → 935
      Flavodoxin_1
    Nucleotide Protein
    Heading Accession and Version

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