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    TICAM1 TIR domain containing adaptor molecule 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574294, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TICAM1provided by VGNC
    Official Full Name
    TIR domain containing adaptor molecule 1provided by VGNC
    Primary source
    VGNC:VGNC:79134
    See related
    Ensembl:ENSMMUG00000014163
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TICAM1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (4749435..4765027, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (4957470..4971110, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein encoded by MIR7-3HG Neighboring gene microRNA mir-7-3 Neighboring gene fem-1 homolog A Neighboring gene perilipin 3 Neighboring gene uncharacterized LOC106994613 Neighboring gene arrestin domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TRIF-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of myeloid dendritic cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TIR domain-containing adapter molecule 1
    Names
    toll like receptor adaptor molecule 1
    toll-interleukin I receptor domain containing adaptor molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130428.1 → NP_001123900.1  TIR domain-containing adapter molecule 1

      See identical proteins and their annotated locations for NP_001123900.1

      Status: PROVISIONAL

      Source sequence(s)
      AB446490
      UniProtKB/TrEMBL
      B3Y697, G7NMI1
      Conserved Domains (2) summary
      pfam12721
      Location:651 → 695
      RHIM; RIP homotypic interaction motif
      cl23749
      Location:398 → 526
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      4749435..4765027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015122534.2 → XP_014978020.2  TIR domain-containing adapter molecule 1 isoform X1

      UniProtKB/TrEMBL
      F6YI17, G7NMI1
      Related
      ENSMMUP00000031953.3, ENSMMUT00000038871.3
      Conserved Domains (3) summary
      pfam09770
      Location:529 → 688
      PAT1; Topoisomerase II-associated protein PAT1
      pfam12721
      Location:657 → 695
      RHIM; RIP homotypic interaction motif
      cl23749
      Location:398 → 526
      TIR_2; TIR domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials