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    DLG3 discs large MAGUK scaffold protein 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697179, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DLG3provided by VGNC
    Official Full Name
    discs large MAGUK scaffold protein 3provided by VGNC
    Primary source
    VGNC:VGNC:71919
    Locus tag
    EGK_20615
    See related
    Ensembl:ENSMMUG00000013948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DLG3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (67490256..67548415)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (65122293..65289481)

    Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 4A Neighboring gene trafficking protein particle complex subunit 2-like protein Neighboring gene uncharacterized LOC106995235 Neighboring gene U4 spliceosomal RNA Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene testis expressed 11 Neighboring gene small integral membrane protein 30 Neighboring gene WASH complex subunit 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disks large homolog 3
    Names
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001194912.2 → NP_001181841.1  disks large homolog 3

      See identical proteins and their annotated locations for NP_001181841.1

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02003166
      UniProtKB/TrEMBL
      F7D6C3, H9FA99
      Related
      ENSMMUP00000041000.2, ENSMMUT00000047963.3
      Conserved Domains (6) summary
      cd12029
      Location:483 → 549
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      smart00228
      Location:224 → 294
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:365 → 443
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:607 → 785
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:292 → 366
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041774.1 Reference Mmul_10 Primary Assembly

      Range
      67490256..67548415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015127624.2 → XP_014983110.1  disks large homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZD27, H9FA99
      Related
      ENSMMUP00000063514.1, ENSMMUT00000100638.1
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:662 → 840
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:329 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 148
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    2. XM_015127623.2 → XP_014983109.1  disks large homolog 3 isoform X1

      UniProtKB/TrEMBL
      F6UBK1, H9FA99
      Related
      ENSMMUP00000040999.2, ENSMMUT00000047962.3
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:676 → 854
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:329 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 148
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    3. XM_015127626.2 → XP_014983112.1  disks large homolog 3 isoform X4

      UniProtKB/TrEMBL
      A0A8J8YFK3, F6SE42, G7NRU6, H9FA99
      Related
      ENSMMUP00000018335.2, ENSMMUT00000019579.4
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:658 → 836
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:329 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 148
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    4. XM_015127627.2 → XP_014983113.1  disks large homolog 3 isoform X5

      UniProtKB/TrEMBL
      H9FA99
      Conserved Domains (5) summary
      cd12029
      Location:520 → 586
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:644 → 822
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:329 → 403
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 148
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    5. XM_015127625.2 → XP_014983111.1  disks large homolog 3 isoform X3

      UniProtKB/TrEMBL
      H9FA99
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:384 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:658 → 836
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:311 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    6. XM_001085782.4 → XP_001085782.2  disks large homolog 3 isoform X6

      See identical proteins and their annotated locations for XP_001085782.2

      UniProtKB/TrEMBL
      H9FA99
      Conserved Domains (5) summary
      cd12029
      Location:502 → 568
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:384 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:626 → 804
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:311 → 385
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:52 → 130
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    7. XM_015127628.2 → XP_014983114.1  disks large homolog 3 isoform X7

      UniProtKB/TrEMBL
      A0A5F8A2Q6, I2CWJ9
      Related
      ENSMMUP00000071640.1, ENSMMUT00000093036.1
      Conserved Domains (3) summary
      cd00992
      Location:48 → 126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:322 → 500
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:166 → 232
      SH3; Src Homology 3 domain superfamily

    8. XM_028841685.1 → XP_028697518.1  disks large homolog 3 isoform X8

      UniProtKB/TrEMBL
      A0A5F8A2Q6
      Conserved Domains (3) summary
      cd12029
      Location:166 → 232
      SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
      cd00992
      Location:48 → 126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:290 → 468
      Guanylate_kin; Guanylate kinase

    9. XM_015127629.2 → XP_014983115.1  disks large homolog 3 isoform X9

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:19 → 85
      SH3; Src Homology 3 domain superfamily

    10. XM_028841687.1 → XP_028697520.1  disks large homolog 3 isoform X9

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:19 → 85
      SH3; Src Homology 3 domain superfamily

    11. XM_028841686.1 → XP_028697519.1  disks large homolog 3 isoform X9

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:19 → 85
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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