nanos nanos [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nanosprovided by FlyBase
Official Full Name: nanosprovided by FlyBase
Primary source: FLYBASE:FBgn0002962
Locus tag: Dmel_CG5637
See related: AllianceGenome:FB:FBgn0002962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5637; Dmel\CG5637; Dronanos; DRONANOS; l(3)07117; l(3)j3B6; l(3)j4B6; Nanos; NANOS; nNOS; nos; Nos; NOS
Summary: Predicted to enable mRNA binding activity. Involved in several processes, including dendrite morphogenesis; germ-line stem cell population maintenance; and negative regulation of synaptic assembly at neuromuscular junction. Located in neuronal ribonucleoprotein granule and postsynapse of neuromuscular junction. Is expressed in several structures, including germarium region 1; germarium region 2; germarium region 2a; germarium region 3; and germline cell. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Orthologous to human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 91F4-91F4; 3-66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19157238..19160202)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14982960..14985924)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.
Title: The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.
The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
Title: The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
Title: Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
Mechanisms ensuring robust repression of the Drosophila female germline stem cell maintenance factor Nanos via posttranscriptional regulation.
Title: Mechanisms ensuring robust repression of the Drosophila female germline stem cell maintenance factor Nanos via posttranscriptional regulation.
dMarf1 translationally represses nos by binding to its mRNA.
Title: Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression.
This study explores the crystallization and structure determination of a Pum-Nos-RNA complex.
Title: Preparation of cooperative RNA recognition complexes for crystallographic structural studies.
Maternal Nanos inhibits Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
Title: Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
Individual nos and pgc transcripts can populate the same nascent germ granule, and these first transcripts then act as seeds, recruiting additional like transcripts to form homotypic clusters.
Title: Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules.
Nos protein has dual functions in translational repression and stabilization of specific RNAs to ensure proper germline development.
Title: Maternal Nanos-Dependent RNA Stabilization in the Primordial Germ Cells of Drosophila Embryos.
Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor proteins has been described.
Title: Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0251 (e-PCR)
- UniSTS:67448

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification, embryo	TAS Traceable Author Statement more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in germ-line stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of translation	TAS Traceable Author Statement more info	PubMed
involved_in oocyte anterior/posterior axis specification	NAS Non-traceable Author Statement more info	PubMed
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in pole plasm	TAS Traceable Author Statement more info	PubMed
located_in postsynapse of neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed